Barrett’s Oesophagus in an Achalasia Patient: Immunological Analysis and Comparison with a Group of Achalasia Patients
Joint Authors
Valdovinos, Miguel A.
Coss-Adame, E.
Torres-Landa, Samuel
Alejandro-Medrano, Edgar
Ramos-Ávalos, Bárbara
Martínez-Benítez, Braulio
Torres-Villalobos, Gonzalo
Furuzawa-Carballeda, Janette
Source
Case Reports in Gastrointestinal Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The aim of the study was to characterize the presence of diverse CD4 and CD8 T cell subsets and regulatory cells in peripheral blood and lower oesophageal sphincter (LES) from a young patient with BE/achalasia without treatment versus achalasia group.
In order to characterize the circulating cells in this patient, a cytometric analysis was performed.
LES tissue was evaluated by double-immunostaining procedure.
Five healthy blood donors, 5 type achalasia patients, and 5 oesophagus tissue samples (gastrooesophageal junction) from transplant donors were included as control groups.
A conspicuous systemic inflammation was determined in BE/achalasia patient and achalasia versus healthy volunteer group.
Nonetheless, a predominance of Th22, Th2, IFN-α-producing T cells, Tregs, Bregs, and pDCregs was observed in BE/achalasia patient versus achalasia group.
A low percentage of Th1 subset in BE/achalasia versus achalasia group was determined.
A noticeable increase in tissue of Th22, Th17, Th2, Tregs, Bregs, and pDCregs was observed in BE/achalasia versus achalasia group.
Th1 subset was lower in the BE/achalasia patient versus achalasia group.
This study suggests that inflammation is a possible factor in the pathogenesis of BE/achalasia.
Further research needs to be performed to understand the specific cause of the correlation between BE and achalasia.
American Psychological Association (APA)
Torres-Landa, Samuel& Furuzawa-Carballeda, Janette& Coss-Adame, E.& Valdovinos, Miguel A.& Alejandro-Medrano, Edgar& Ramos-Ávalos, Bárbara…[et al.]. 2016. Barrett’s Oesophagus in an Achalasia Patient: Immunological Analysis and Comparison with a Group of Achalasia Patients. Case Reports in Gastrointestinal Medicine،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1100801
Modern Language Association (MLA)
Torres-Landa, Samuel…[et al.]. Barrett’s Oesophagus in an Achalasia Patient: Immunological Analysis and Comparison with a Group of Achalasia Patients. Case Reports in Gastrointestinal Medicine No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1100801
American Medical Association (AMA)
Torres-Landa, Samuel& Furuzawa-Carballeda, Janette& Coss-Adame, E.& Valdovinos, Miguel A.& Alejandro-Medrano, Edgar& Ramos-Ávalos, Bárbara…[et al.]. Barrett’s Oesophagus in an Achalasia Patient: Immunological Analysis and Comparison with a Group of Achalasia Patients. Case Reports in Gastrointestinal Medicine. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1100801
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1100801