Disseminated Cryptococcal Disease in a Patient with Chronic Lymphocytic Leukemia on Ibrutinib
Joint Authors
Okamoto, Koh
Proia, Laurie A.
Demarais, Patricia L.
Source
Case Reports in Infectious Diseases
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-14
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Cryptococcus is a unique environmental fungus that can cause disease most often in immunocompromised individuals with defective cell-mediated immunity.
Chronic lymphocytic leukemia (CLL) is not known to be a risk factor for cryptococcal disease although cases have been described mainly in patients treated with agents that suppress cell-mediated immunity.
Ibrutinib is a new biologic agent used for treatment of CLL, mantle cell lymphoma, and Waldenstrom’s macroglobulinemia.
It acts by inhibiting Bruton’s tyrosine kinase, a kinase downstream of the B-cell receptor critical for B-cell survival and proliferation.
Ibrutinib use has not been associated previously with cryptococcal disease.
However, recent evidence suggested that treatments aimed at blocking the function of Bruton’s tyrosine kinase could pose a higher risk for cryptococcal infection in a mice model.
Here, we report the first case of disseminated cryptococcal disease in a patient with CLL treated with ibrutinib.
When evaluating possible infection in CLL patients receiving ibrutinib, cryptococcal disease, which could be life threatening if overlooked, could be considered.
American Psychological Association (APA)
Okamoto, Koh& Proia, Laurie A.& Demarais, Patricia L.. 2016. Disseminated Cryptococcal Disease in a Patient with Chronic Lymphocytic Leukemia on Ibrutinib. Case Reports in Infectious Diseases،Vol. 2016, no. 2016, pp.1-3.
https://search.emarefa.net/detail/BIM-1100979
Modern Language Association (MLA)
Okamoto, Koh…[et al.]. Disseminated Cryptococcal Disease in a Patient with Chronic Lymphocytic Leukemia on Ibrutinib. Case Reports in Infectious Diseases No. 2016 (2016), pp.1-3.
https://search.emarefa.net/detail/BIM-1100979
American Medical Association (AMA)
Okamoto, Koh& Proia, Laurie A.& Demarais, Patricia L.. Disseminated Cryptococcal Disease in a Patient with Chronic Lymphocytic Leukemia on Ibrutinib. Case Reports in Infectious Diseases. 2016. Vol. 2016, no. 2016, pp.1-3.
https://search.emarefa.net/detail/BIM-1100979
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1100979