Concomitant Use of Topiramate Inducing Neutropenia in a Schizophrenic Male Stabilized on Clozapine
Joint Authors
Sharma, Pravesh
Davis, Jeffrey
Rachamallu, Vivekananda
Aligeti, Manish
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-24
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
This is a case of a 23-year-old African American male with a history of paranoid schizophrenia that developed neutropenia on a clozapine-topiramate therapy.
Clozapine had well addressed the patient’s psychotic symptoms, while topiramate was used as a weight-lowering agent.
The patient had fairly stable leukocyte counts for eight months on clozapine 300 mg and topiramate 100 mg daily.
Doubling the dosage of topiramate led to severe neutropenia after two months.
Reviewing the patient’s laboratory reports showed a gradual decline of neutrophils occurring at a lower dosage, followed by a rapid decline after an increased dosage.
In this case, we report that not only did topiramate act as the neutropenic agent, but also it might have done so in a dose-dependent manner.
American Psychological Association (APA)
Sharma, Pravesh& Davis, Jeffrey& Rachamallu, Vivekananda& Aligeti, Manish. 2016. Concomitant Use of Topiramate Inducing Neutropenia in a Schizophrenic Male Stabilized on Clozapine. Case Reports in Psychiatry،Vol. 2016, no. 2016, pp.1-3.
https://search.emarefa.net/detail/BIM-1102500
Modern Language Association (MLA)
Sharma, Pravesh…[et al.]. Concomitant Use of Topiramate Inducing Neutropenia in a Schizophrenic Male Stabilized on Clozapine. Case Reports in Psychiatry No. 2016 (2016), pp.1-3.
https://search.emarefa.net/detail/BIM-1102500
American Medical Association (AMA)
Sharma, Pravesh& Davis, Jeffrey& Rachamallu, Vivekananda& Aligeti, Manish. Concomitant Use of Topiramate Inducing Neutropenia in a Schizophrenic Male Stabilized on Clozapine. Case Reports in Psychiatry. 2016. Vol. 2016, no. 2016, pp.1-3.
https://search.emarefa.net/detail/BIM-1102500
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1102500