Impact of Rosuvastatin Treatment on HDL-Induced PKC-βII and eNOS Phosphorylation in Endothelial Cells and Its Relation to Flow-Mediated Dilatation in Patients with Chronic Heart Failure
Joint Authors
Adams, Volker
Fischer, Tina
Schuler, Gerhard
Winzer, Ephraim B.
Gaida, Pauline
Höllriegel, Robert
Linke, Axel
Erbs, Sandra
Source
Cardiology Research and Practice
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-02
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Endothelial function is impaired in chronic heart failure (CHF).
Statins upregulate endothelial NO synthase (eNOS) and improve endothelial function.
Recent studies demonstrated that HDL stimulates NO production due to eNOS phosphorylation at Ser1177, dephosphorylation at Thr495, and diminished phosphorylation of PKC-βII at Ser660.
The aim of this study was to elucidate the impact of rosuvastatin on HDL mediated eNOS and PKC-βII phosphorylation and its relation to endothelial function.
Methods.
18 CHF patients were randomized to 12 weeks of rosuvastatin or placebo.
At baseline, 12 weeks, and 4 weeks after treatment cessation we determined lipid levels and isolated HDL.
Human aortic endothelial cells (HAEC) were incubated with isolated HDL and phosphorylation of eNOS and PKC-βII was evaluated.
Flow-mediated dilatation (FMD) was measured at the radial artery.
Results.
Rosuvastatin improved FMD significantly.
This effect was blunted after treatment cessation.
LDL plasma levels were reduced after rosuvastatin treatment whereas drug withdrawal resulted in significant increase.
HDL levels remained unaffected.
Incubation of HAEC with HDL had no impact on phosphorylation of eNOS or PKC-βII.
Conclusion.
HDL mediated eNOS and PKC-βII phosphorylation levels in endothelial cells do not change with rosuvastatin in CHF patients and do not mediate the marked improvement in endothelial function.
American Psychological Association (APA)
Winzer, Ephraim B.& Gaida, Pauline& Höllriegel, Robert& Fischer, Tina& Linke, Axel& Schuler, Gerhard…[et al.]. 2016. Impact of Rosuvastatin Treatment on HDL-Induced PKC-βII and eNOS Phosphorylation in Endothelial Cells and Its Relation to Flow-Mediated Dilatation in Patients with Chronic Heart Failure. Cardiology Research and Practice،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1103289
Modern Language Association (MLA)
Winzer, Ephraim B.…[et al.]. Impact of Rosuvastatin Treatment on HDL-Induced PKC-βII and eNOS Phosphorylation in Endothelial Cells and Its Relation to Flow-Mediated Dilatation in Patients with Chronic Heart Failure. Cardiology Research and Practice No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1103289
American Medical Association (AMA)
Winzer, Ephraim B.& Gaida, Pauline& Höllriegel, Robert& Fischer, Tina& Linke, Axel& Schuler, Gerhard…[et al.]. Impact of Rosuvastatin Treatment on HDL-Induced PKC-βII and eNOS Phosphorylation in Endothelial Cells and Its Relation to Flow-Mediated Dilatation in Patients with Chronic Heart Failure. Cardiology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1103289
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103289