![](/images/graphics-bg.png)
Dynamics of SOX2 and CDX2 Expression in Barrett’s Mucosa
Joint Authors
Barros, Rita
Pereira, Daniela
Callé, Catarina
Camilo, Vânia
Cunha, Ana Isabel
Almeida, Raquel
Dias-Pereira, António
Chaves, Paula
David, L.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-27
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Barrett’s esophagus (BE) is the replacement of the normal esophageal squamous epithelium by a columnar lining epithelium.
It is a premalignant condition for the development of adenocarcinoma of the esophagus and esophagogastric junction.
BE is associated with gastroesophageal reflux which might change the expression profile of key transcription factors involved in the establishment of tissue differentiation, namely, SOX2 (associated with esophageal and gastric differentiation) and CDX2 (associated with intestinal differentiation).
Here, we sought to characterize the expression profile of SOX2 and CDX2 in the sequential alterations of the esophageal mucosa towards adenocarcinoma and compare it with the well-established gastric and intestinal mucin profiles (MUC5AC, MUC6, and MUC2).
We observed that SOX2 and CDX2 expression correlates with gastric and intestinal differentiation in BE, defined by morphological parameters and mucin expression.
We show the presence of a complete intestinal profile in BE, without gastric mucins and without SOX2, and we observed an evolutionary modulation of the metaplastic phenotype by SOX2 and CDX2.
We observed that adenocarcinomas harbor more frequently a mixed gastric and intestinal phenotype.
In conclusion, our study establishes a role for transcription factors SOX2 and CDX2 in the progression from gastric to gastrointestinal differentiation in Barrett’s metaplasia.
American Psychological Association (APA)
Barros, Rita& Pereira, Daniela& Callé, Catarina& Camilo, Vânia& Cunha, Ana Isabel& David, L.…[et al.]. 2016. Dynamics of SOX2 and CDX2 Expression in Barrett’s Mucosa. Disease Markers،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1103656
Modern Language Association (MLA)
Barros, Rita…[et al.]. Dynamics of SOX2 and CDX2 Expression in Barrett’s Mucosa. Disease Markers No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1103656
American Medical Association (AMA)
Barros, Rita& Pereira, Daniela& Callé, Catarina& Camilo, Vânia& Cunha, Ana Isabel& David, L.…[et al.]. Dynamics of SOX2 and CDX2 Expression in Barrett’s Mucosa. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1103656
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103656