The Markers of Glutamate Metabolism in Peripheral Blood Mononuclear Cells and Neurological Complications in Lung Cancer Patients
Joint Authors
Michalak, Slawomir
Rybacka-Mossakowska, Joanna
Ambrosius, Wojciech
Gazdulska, Joanna
Gołda-Gocka, Iwona
Kozubski, Wojciech
Ramlau, Rodryg
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
To evaluate the involvement of glutamate metabolism in peripheral blood mononuclear cells (PBMC) in the development of neurological complications in lung cancer and during chemotherapy.
Methods.
The prospective study included 221 lung cancer patients treated with chemotherapeutics.
Neurological status and cognitive functions were evaluated at baseline and after 6-month follow-up.
Glutamate level, the activities of glutaminase- (GLS-) glutamate synthetizing enzyme, glutamate dehydrogenase (GDH), and glutamate decarboxylase catalyzing glutamate degradation were analyzed in PBMC and in sera of lung cancer patients by means of spectrophotometric and colorimetric methods.
Results.
Chemotherapy of lung neoplasms induced increase of glutamate content in PBMC and its concentration in serum increased the activity of GDH in PBMC and decreased activity of glutaminase in PBMC.
The changes in glutamate metabolism markers were associated with initial manifestation of neurological deficit in lung cancer patients and with new symptoms, which appear as a complication of chemotherapy.
Moreover, the analyzed parameters of glutamate control correlated with a spectrum of cognitive functions measures in lung cancer patients.
Conclusion.
We have demonstrated dysregulation in glutamate and glutamate metabolism controlling enzymes as promising indicators of risk for chemotherapy-induced neurological complications in lung cancer patients with particular emphasis on cognitive impairment.
American Psychological Association (APA)
Michalak, Slawomir& Rybacka-Mossakowska, Joanna& Ambrosius, Wojciech& Gazdulska, Joanna& Gołda-Gocka, Iwona& Kozubski, Wojciech…[et al.]. 2016. The Markers of Glutamate Metabolism in Peripheral Blood Mononuclear Cells and Neurological Complications in Lung Cancer Patients. Disease Markers،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1103679
Modern Language Association (MLA)
Michalak, Slawomir…[et al.]. The Markers of Glutamate Metabolism in Peripheral Blood Mononuclear Cells and Neurological Complications in Lung Cancer Patients. Disease Markers No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1103679
American Medical Association (AMA)
Michalak, Slawomir& Rybacka-Mossakowska, Joanna& Ambrosius, Wojciech& Gazdulska, Joanna& Gołda-Gocka, Iwona& Kozubski, Wojciech…[et al.]. The Markers of Glutamate Metabolism in Peripheral Blood Mononuclear Cells and Neurological Complications in Lung Cancer Patients. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1103679
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103679