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Tumor Necrosis Factor-α T-857C (rs1799724) Polymorphism and Risk of Cancers: A Meta-Analysis
Joint Authors
Wang, Ping
Yu, Mingxia
Wang, June
Li, Zhiqiang
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objectives.
To investigate the potential association of tumor necrosis factor-α T-857C polymorphism with susceptibility to the five common malignant tumors.
Materials and Methods.
A comprehensive search of PubMed/Medline, Embase, and Web of Science databases was performed up to November 2015.
Pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated to assess the strength of the association.
Subgroup analysis, heterogeneity analyses, and publication bias were also texted in the meta-analysis.
Results.
A total of twenty-two publications involving 5215 cases and 6755 controls were recruited.
Overall, the meta-analysis revealed an increased risk between the TNF-α T-857C polymorphism and gastric cancer susceptibility in T versus C model, heterozygote genetic model, and dominant genetic model.
An increased risk between the TNF-α T-857C polymorphism and hepatocellular cancer susceptibility in homozygote genetic model and recessive genetic model was also found.
No significant association was found between the TNF-α T-857C polymorphism and colorectal cancer, cervical cancer, and prostate cancer.
Conclusions.
Our meta-analyses suggest that TNF-α T-857C polymorphism may be associated with increased risk of gastric cancer and hepatocellular cancer development.
Therefore, the TNF-α T-857C polymorphism could be considered as one possible risk factor of gastric cancer and hepatocellular cancer according to our study.
American Psychological Association (APA)
Wang, Ping& Wang, June& Yu, Mingxia& Li, Zhiqiang. 2016. Tumor Necrosis Factor-α T-857C (rs1799724) Polymorphism and Risk of Cancers: A Meta-Analysis. Disease Markers،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1103707
Modern Language Association (MLA)
Wang, Ping…[et al.]. Tumor Necrosis Factor-α T-857C (rs1799724) Polymorphism and Risk of Cancers: A Meta-Analysis. Disease Markers No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1103707
American Medical Association (AMA)
Wang, Ping& Wang, June& Yu, Mingxia& Li, Zhiqiang. Tumor Necrosis Factor-α T-857C (rs1799724) Polymorphism and Risk of Cancers: A Meta-Analysis. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1103707
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103707