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The Effect of Poly(ADP-ribose) Polymerase-1 Gene 3′Untranslated Region Polymorphism in Colorectal Cancer Risk among Saudi Cohort
Joint Authors
Alanazi, Mohammed
Semlali, Abdelhabib
Alamri, Abdullah
Alhadheq, Abdullah M.
Aljebreen, Abdulrahman M.
Alharbi, Othman
Almadi, Majid A.
Alhadeq, Faten
Azzam, Nahla A.
Bazzi, Mohammad D.
Purusottapatnam Shaik, Jilani
Reddy Parine, Narasimha
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-25
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
DNA repair systems are essential for each cell to repair and maintain the genome integrity.
Base excision repair pathway is one of the crucial pathways to maintain genome integrity and PARP-1 plays a key role in BER pathway.
The purpose of this study is to evaluate the association between polymorphisms in PARP-1 3′untranslated region (3′UTR) SNP rs8679 and its expression in colorectal cancer.
Methods.
Genotyping and gene expression were performed using TaqMan assays.
The effects of age, gender, and tumor location were evaluated in cases and controls regarding the genotyping results.
Resulting data was analyzed using SPSS software.
Results and Conclusions.
Genotyping analysis for SNP rs8679 showed decreased susceptibility to colorectal cancer at heterozygous TC allele and at minor allele C.
Further this protective association was also observed in younger age patients (≤57), in female patients, and also in patients with tumors located at colon and rectum.
PARP-1 expression levels are significantly different in colorectal cancer compared to matched normal tissue.
Our findings proved that the upregulation of PARP-1 is associated with tumor progression and poor prognosis in Saudi patients with colorectal cancer, suggesting that PARP-1 can be novel and valuable signatures for predicting the clinical outcome of patients with colorectal cancer.
American Psychological Association (APA)
Alhadheq, Abdullah M.& Purusottapatnam Shaik, Jilani& Alamri, Abdullah& Aljebreen, Abdulrahman M.& Alharbi, Othman& Almadi, Majid A.…[et al.]. 2016. The Effect of Poly(ADP-ribose) Polymerase-1 Gene 3′Untranslated Region Polymorphism in Colorectal Cancer Risk among Saudi Cohort. Disease Markers،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1103786
Modern Language Association (MLA)
Alhadheq, Abdullah M.…[et al.]. The Effect of Poly(ADP-ribose) Polymerase-1 Gene 3′Untranslated Region Polymorphism in Colorectal Cancer Risk among Saudi Cohort. Disease Markers No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1103786
American Medical Association (AMA)
Alhadheq, Abdullah M.& Purusottapatnam Shaik, Jilani& Alamri, Abdullah& Aljebreen, Abdulrahman M.& Alharbi, Othman& Almadi, Majid A.…[et al.]. The Effect of Poly(ADP-ribose) Polymerase-1 Gene 3′Untranslated Region Polymorphism in Colorectal Cancer Risk among Saudi Cohort. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1103786
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103786