Long Noncoding RNAs as Novel Biomarkers Have a Promising Future in Cancer Diagnostics
Joint Authors
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-10
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Cancers have a high mortality rate due to lack of suitable specific early diagnosis tumor biomarkers.
Emerging evidence is accumulating that lncRNAs (long noncoding RNAs) are involved in tumorigenesis, tumor cells proliferation, invasion, migration, apoptosis, and angiogenesis.
Furthermore, extracellular lncRNAs can circulate in body fluids; they can be detected and strongly resist RNases.
Many researchers have found that lncRNAs could be good candidates for tumor biomarkers and possessed high specificity, high sensitivity, and noninvasive characteristics.
In this review, we summarize the detection methods and possible sources of circulating lncRNAs and outline the biological functions and expression level of the most significant lncRNAs in tissues, cell lines, and body fluids (whole blood, plasma, urine, gastric juice, and saliva) of different kinds of tumors.
We evaluate the diagnostic performance of lncRNAs as tumor biomarkers.
However, the biological functions and the mechanisms of circulating lncRNAs secretion have not been fully understood.
The uniform normalization protocol of sample collection, lncRNAs extraction, endogenous control selection, quality assessment, and quantitative data analysis has not been established.
Therefore, we put forward some recommendations that might be investigated in the future if we want to adopt lncRNAs in clinical practice.
American Psychological Association (APA)
Shi, Ting& Gao, Ge& Cao, Yingli. 2016. Long Noncoding RNAs as Novel Biomarkers Have a Promising Future in Cancer Diagnostics. Disease Markers،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1103800
Modern Language Association (MLA)
Shi, Ting…[et al.]. Long Noncoding RNAs as Novel Biomarkers Have a Promising Future in Cancer Diagnostics. Disease Markers No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1103800
American Medical Association (AMA)
Shi, Ting& Gao, Ge& Cao, Yingli. Long Noncoding RNAs as Novel Biomarkers Have a Promising Future in Cancer Diagnostics. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1103800
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103800