Effect of Kuijie Granule on the Expression of TGF-βSmads Signaling Pathway in Patients with Ulcerative Colitis
Joint Authors
Xu, Xinjie
Xu, Chunhua
Saud, Shakir M.
Lu, Xiaoming
Liu, Lei
Fang, Li
Zhang, Xiaowei
Hu, Jiangong
Li, Weidong
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-25
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The dysregulation of TGF-β/Smads signaling pathway has been postulated to contribute to the development of ulcerative colitis (UC) and the manifestation of clinical symptoms.
Kuijie Granule is a prescription medicine used clinically in China to alleviate the symptoms associated with UC.
To evaluate whether the clinical benefit of Kuijie Granule is associated with TGF-β/Smads signaling, we measured the expression levels of TGF-β/Smads signaling proteins (TGF-β1, TGF-βRII, Smad2, Smad4, Smad6, and Smad7) in the intestinal mucosa of 72 patients with UC treated with Kuijie Granule for 60 days.
Colonic tissues were obtained by a virtual colonoscopy guided biopsy before and after Kuijie Granule treatment followed by pathological analysis and quantitative analysis of TGF-β/Smads using immunohistochemistry.
Kuijie Granule treatment significantly improved symptoms associated with UC, which include diarrhea, mucus production, pus and blood in stool, abdominal pain and distention, and tenesmus.
The clinical benefit of Kuijie Granule treatment correlated with decreased expression of TGF-β1 and Smad7 and increased expression of TGF-βRII and Smad4.
These clinical results indicate that Kuijie Granule can alleviate the symptoms associated with UC and modulate TGF-β/Smads signaling.
American Psychological Association (APA)
Xu, Xinjie& Xu, Chunhua& Saud, Shakir M.& Lu, Xiaoming& Liu, Lei& Fang, Li…[et al.]. 2016. Effect of Kuijie Granule on the Expression of TGF-βSmads Signaling Pathway in Patients with Ulcerative Colitis. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104000
Modern Language Association (MLA)
Xu, Xinjie…[et al.]. Effect of Kuijie Granule on the Expression of TGF-βSmads Signaling Pathway in Patients with Ulcerative Colitis. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1104000
American Medical Association (AMA)
Xu, Xinjie& Xu, Chunhua& Saud, Shakir M.& Lu, Xiaoming& Liu, Lei& Fang, Li…[et al.]. Effect of Kuijie Granule on the Expression of TGF-βSmads Signaling Pathway in Patients with Ulcerative Colitis. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104000
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104000