A Transmembrane Polymorphism of Fcγ Receptor IIb Is Associated with Kidney Deficiency Syndrome in Rheumatoid Arthritis
Joint Authors
Mo, Na
Lai, Ruogu
Luo, Shizi
Xie, Jianglin
Wang, Xizi
Liu, Lijuan
Liu, Xiaoling
Chen, Guangxing
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-08
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
The purpose is to investigate the role of kidney deficiency and the association between kidney deficiency and a polymorphism FcγRIIb 695T>C coding for nonsynonymous substitution IIe232Thr (I232T) in rheumatoid arthritis (RA).
Methods.
Clinical parameters and autoantibodies were analyzed and genotyping was performed in 159 kidney deficiency and 161 non-kidney-deficiency RA patients.
Results.
The age of disease onset and disease duration exhibited significant differences between two groups ( P < 0.01 ).
Patients with kidney deficiency tend to have higher activity of disease ( P < 0.05 ).
Anti-cyclic citrullinated peptides antibodies (ACPA) levels of patients with kidney deficiency were higher than the controls ( P = 0.039 ).
125 (78.6%) kidney deficiency and 114 (70.8%) non-kidney-deficiency patients had both ACPA-positive and RF-positive ( P = 0.04 , OR = 3.29).
FcγRIIb I232TT homozygotes were identified in 10 of 159 (6.3%) kidney deficiency subjects and 1 of 161 (0.6%) controls ( P = 0.000 , OR = 16.45).
Furthermore, in pooled genotype analysis, I232IT and I232TT homozygotes were significantly enriched in kidney deficiency individuals compared with the controls ( P = 0.000 , OR = 3.79).
Frequency of T allele was associated with kidney deficiency RA population ( P = 0.000 , OR = 3.18).
Conclusion.
This study confirmed that kidney deficiency was closely associated with disease activity and autoimmune disorder in RA.
Kidney deficiency in RA is first to reveal a strong genetic link to FcγRIIb variants.
American Psychological Association (APA)
Mo, Na& Lai, Ruogu& Luo, Shizi& Xie, Jianglin& Wang, Xizi& Liu, Lijuan…[et al.]. 2016. A Transmembrane Polymorphism of Fcγ Receptor IIb Is Associated with Kidney Deficiency Syndrome in Rheumatoid Arthritis. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1104056
Modern Language Association (MLA)
Mo, Na…[et al.]. A Transmembrane Polymorphism of Fcγ Receptor IIb Is Associated with Kidney Deficiency Syndrome in Rheumatoid Arthritis. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1104056
American Medical Association (AMA)
Mo, Na& Lai, Ruogu& Luo, Shizi& Xie, Jianglin& Wang, Xizi& Liu, Lijuan…[et al.]. A Transmembrane Polymorphism of Fcγ Receptor IIb Is Associated with Kidney Deficiency Syndrome in Rheumatoid Arthritis. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1104056
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104056