Herb-Drug Interaction: Effects of Relinqing® Granule on the Pharmacokinetics of Ciprofloxacin, Sulfamethoxazole, and Trimethoprim in Rats
Joint Authors
Gong, Zipeng
Lu, Yuan
Xie, YuMin
Pan, Jie
Sun, Jia
Li, YueTing
Chen, SiYing
Li, YongJun
Wang, YongLin
Huang, Yong
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-04
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Relinqing granule (RLQ) is the best-selling Chinese patent drug for treatment of urinary system diseases.
In this study, the effects of RLQ on the pharmacokinetics of ciprofloxacin, sulfamethoxazole, and trimethoprim in SD rats were investigated.
Rats were randomly divided into control group 1, control group 2, RLQ group 1, and RLQ group 2.
RLQ group 1 and RLQ group 2 were treated orally with RLQ for 7 days, and rats were treated with the same volume of water in control group 1 and control group 2.
Then, RLQ group 1 and control group 1 were given intragastrically ciprofloxacin on day 8, while RLQ group 2 and control group 2 were given intragastrically sulfamethoxazole and trimethoprim on day 8.
Blood samples were collected and determined.
There was no significant influence of pharmacokinetic parameters of trimethoprim on two groups.
But some pharmacokinetic parameters of ciprofloxacin and sulfamethoxazole in RLQ pretreated rats were evidently altered (P < 0.05), which indicated that absorption of ciprofloxacin and sulfamethoxazole in RLQ pretreated rats was significantly affected.
It indicated the coadministration of RLQ would have an influence on the efficacy of ciprofloxacin and sulfamethoxazole, and the doses of ciprofloxacin tablet and compound sulfamethoxazole tablet need adjustment.
American Psychological Association (APA)
Lu, Yuan& Gong, Zipeng& Xie, YuMin& Pan, Jie& Sun, Jia& Li, YueTing…[et al.]. 2016. Herb-Drug Interaction: Effects of Relinqing® Granule on the Pharmacokinetics of Ciprofloxacin, Sulfamethoxazole, and Trimethoprim in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1104271
Modern Language Association (MLA)
Lu, Yuan…[et al.]. Herb-Drug Interaction: Effects of Relinqing® Granule on the Pharmacokinetics of Ciprofloxacin, Sulfamethoxazole, and Trimethoprim in Rats. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1104271
American Medical Association (AMA)
Lu, Yuan& Gong, Zipeng& Xie, YuMin& Pan, Jie& Sun, Jia& Li, YueTing…[et al.]. Herb-Drug Interaction: Effects of Relinqing® Granule on the Pharmacokinetics of Ciprofloxacin, Sulfamethoxazole, and Trimethoprim in Rats. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1104271
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104271