Protection Efficacy of the Extract of Ginkgo biloba against the Learning and Memory Damage of Rats under Repeated High Sustained +Gz Exposure
Joint Authors
Chen, Liang-En
Wu, Feng
Zhao, Andong
Ge, Hua
Zhan, Hao
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-16
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Repeated high sustained positive Gz (+Gz) exposures are known for the harmful pathophysiological impact on the brain of rats, which is reflected as the interruption of normal performance of learning and memory.
Interestingly, extract of Ginkgo biloba (EGb) has been reported to have neuroprotective effects and cognition-enhancing effects.
In this study, we are interested in evaluating the protective effects of EGb toward the learning and memory abilities.
Morris Water Maze Test (MWM) was used to evaluate the cognitive function, and the physiological status of the key components in central cholinergic system was also investigated.
Our animal behavioral tests indicated that EGb can release the learning and memory impairment caused by repeated high sustained +Gz.
Administration of EGb to rats can diminish some of the harmful physiological effects caused by repeated +Gz exposures.
Moreover, EGb administration can increase the biological activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) but reduce the production of malondialdehyde (MDA).
Taken together, our study showed that EGb can ameliorate the impairment of learning and memory abilities of rats induced by repeated high sustained +Gz exposure; the underlying mechanisms appeared to be related to the signal regulation on the cholinergic system and antioxidant enzymes system.
American Psychological Association (APA)
Chen, Liang-En& Wu, Feng& Zhao, Andong& Ge, Hua& Zhan, Hao. 2016. Protection Efficacy of the Extract of Ginkgo biloba against the Learning and Memory Damage of Rats under Repeated High Sustained +Gz Exposure. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1104278
Modern Language Association (MLA)
Chen, Liang-En…[et al.]. Protection Efficacy of the Extract of Ginkgo biloba against the Learning and Memory Damage of Rats under Repeated High Sustained +Gz Exposure. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1104278
American Medical Association (AMA)
Chen, Liang-En& Wu, Feng& Zhao, Andong& Ge, Hua& Zhan, Hao. Protection Efficacy of the Extract of Ginkgo biloba against the Learning and Memory Damage of Rats under Repeated High Sustained +Gz Exposure. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1104278
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104278