Dendrobium officinale Prevents Early Complications in Streptozotocin-Induced Diabetic Rats
Joint Authors
Hou, Shao-Zhen
Liang, Chu-yan
Liu, Hua-zhen
Zhu, Dong-mei
Wu, Ya-yun
Liang, Jian
Zhao, Ya
Guo, Jian-ru
Huang, Song
Lai, Xiao-Ping
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-29
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
Dendrobium officinale (DO) Kimura et Migo is a precious Chinese herb that is considered beneficial for health due to its antioxidant and antidiabetes properties, and so on.
In this research, we try to determine the preventive effect of DO on the early complications of STZ-induced diabetic rats.
Methods.
Type 1 diabetic rats were produced with a single intraperitoneal injection of STZ (50 mg/kg).
DO (1 g/kg/day) was then orally administered for 5 weeks.
Blood glucose, TC, TG, BUN, CREA, and GSH-PX levels were determined, and electroretinographic activity and hypoalgesia were investigated.
Pathological sections of the eyes, hearts, aortas, kidneys, and livers were analyzed.
Results.
Treatment with DO significantly attenuated the serum levels of TC, TG, BUN, and CREA, markedly increased the amplitudes of ERG a- and b-waves and Ops, and reduced the hypoalgesia and histopathological changes of vital organs induced by hyperglycemia.
The protective effect of DO in diabetic rats may be associated with its antioxidant activity, as evidenced by the marked increase in the serum level of glutathione peroxidase.
However, DO had no significant effect on blood glucose levels and bodyweight of diabetic rats.
Conclusions.
DO supplementation is an effective treatment to prevent STZ-induced diabetic complications.
American Psychological Association (APA)
Hou, Shao-Zhen& Liang, Chu-yan& Liu, Hua-zhen& Zhu, Dong-mei& Wu, Ya-yun& Liang, Jian…[et al.]. 2016. Dendrobium officinale Prevents Early Complications in Streptozotocin-Induced Diabetic Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1104282
Modern Language Association (MLA)
Hou, Shao-Zhen…[et al.]. Dendrobium officinale Prevents Early Complications in Streptozotocin-Induced Diabetic Rats. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1104282
American Medical Association (AMA)
Hou, Shao-Zhen& Liang, Chu-yan& Liu, Hua-zhen& Zhu, Dong-mei& Wu, Ya-yun& Liang, Jian…[et al.]. Dendrobium officinale Prevents Early Complications in Streptozotocin-Induced Diabetic Rats. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1104282
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104282