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Effect of Betula pendula Leaf Extract on α-Glucosidase and Glutathione Level in Glucose-Induced Oxidative Stress
Joint Authors
Bljajić, Kristina
Šoštarić, Nina
Petlevski, Roberta
Vujić, Lovorka
Brajković, Andrea
Fumić, Barbara
de Carvalho, Isabel Saraiva
Končić, Marijana Zovko
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-07
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
B.
pendula leaf is a common ingredient in traditional herbal combinations for treatment of diabetes in southeastern Europe.
Present study investigated B.
pendula ethanolic and aqueous extract as inhibitors of carbohydrate hydrolyzing enzymes, as well as their ability to restore glutathione concentration in Hep G2 cells subjected to glucose-induced oxidative stress.
Phytochemical analysis revealed presence of rutin and other quercetin derivatives, as well as chlorogenic acid.
In general, ethanolic extract was richer in phenolic substances than the aqueous extract.
Furthermore, a comprehensive analysis of antioxidant activity of two extracts (determined by DPPH and ABTS radical scavenging activity, total antioxidant activity, and chelating activity as well as ferric-reducing antioxidant power) has shown that ethanolic extract was better radical scavenger and metal ion reductant.
In addition, ethanolic extract effectively increased cellular glutathione levels caused by hyperglycemia and inhibited α-glucosidase with the activity comparable to that of acarbose.
Therefore, in vitro research using B.
pendula plant extracts has confirmed their antidiabetic properties.
American Psychological Association (APA)
Bljajić, Kristina& Šoštarić, Nina& Petlevski, Roberta& Vujić, Lovorka& Brajković, Andrea& Fumić, Barbara…[et al.]. 2016. Effect of Betula pendula Leaf Extract on α-Glucosidase and Glutathione Level in Glucose-Induced Oxidative Stress. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104425
Modern Language Association (MLA)
Bljajić, Kristina…[et al.]. Effect of Betula pendula Leaf Extract on α-Glucosidase and Glutathione Level in Glucose-Induced Oxidative Stress. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1104425
American Medical Association (AMA)
Bljajić, Kristina& Šoštarić, Nina& Petlevski, Roberta& Vujić, Lovorka& Brajković, Andrea& Fumić, Barbara…[et al.]. Effect of Betula pendula Leaf Extract on α-Glucosidase and Glutathione Level in Glucose-Induced Oxidative Stress. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104425
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104425