The Preventive Effect of Zuogui Wan on Offspring Rats’ Impaired Glucose Tolerance Whose Mothers Had Gestational Diabetes Mellitus

Joint Authors

Feng, Qianjin
Wang, Yuwei
Li, Qiuju
Niu, Xin
Wang, Yingli
Wang, Jinlong
Mao, Yingqiu
Gao, Shuangrong
Xu, Kaixia

Source

Evidence-Based Complementary and Alternative Medicine

Issue

Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2016-02-29

Country of Publication

Egypt

No. of Pages

8

Main Subjects

Medicine

Abstract EN

In this experiment, we used streptozotocin (STZ) to establish a model of gestational diabetes mellitus (GDM) rats, where Zuogui Wan was given to GDM rats.

After pregnancy, offspring rats were divided into 4 groups: control group, high fat and sugar as the control group, GDM group, and Zuogui Wan GDM group.

Rats in high fat and sugar as the control group, GDM group, and Zuogui Wan GDM group were fed with high fat and sugar diet.

Rats in control group were fed the basic diet.

The means of 2hPG were higher than 7.8 mmol·L−1 and lower than 11.1 mmol·L−1 on the rats of GDM group on week 15, and IGT models were successful.

Body weight, abdominal fat weight, the ratio of abdominal fat weight and body weight, fasting plasma glucose, 2hPG, insulin, leptin, total cholesterol, and low density lipoprotein (LDL) of Zuogui Wan GDM group were significantly lower than GDM group.

The level of adiponectin in Zuogui Wan GDM group was significantly higher than GDM group.

And we concluded that giving Zuogui Wan to GDM rats can have a preventive effect on the offsprings’ IGT induced by high fat and sugar diet.

American Psychological Association (APA)

Wang, Yuwei& Feng, Qianjin& Niu, Xin& Xu, Kaixia& Wang, Yingli& Wang, Jinlong…[et al.]. 2016. The Preventive Effect of Zuogui Wan on Offspring Rats’ Impaired Glucose Tolerance Whose Mothers Had Gestational Diabetes Mellitus. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104500

Modern Language Association (MLA)

Wang, Yuwei…[et al.]. The Preventive Effect of Zuogui Wan on Offspring Rats’ Impaired Glucose Tolerance Whose Mothers Had Gestational Diabetes Mellitus. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1104500

American Medical Association (AMA)

Wang, Yuwei& Feng, Qianjin& Niu, Xin& Xu, Kaixia& Wang, Yingli& Wang, Jinlong…[et al.]. The Preventive Effect of Zuogui Wan on Offspring Rats’ Impaired Glucose Tolerance Whose Mothers Had Gestational Diabetes Mellitus. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104500

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1104500