Flavonoids and Sesquiterpene Lactones from Artemisia absinthium and Tanacetum parthenium against Schistosoma mansoni Worms
Joint Authors
Aleixo de Carvalho, Lara Soares
de Moraes, Josué
Pinto, Pedro Luiz Silva
de Almeida, Luísa Maria Silveira
Gazolla, Matheus Coutinho
Silva, Marcos Paulo Nascimento da
Da Silva Filho, Ademar A.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Human schistosomiasis, caused by trematode worms of the genus Schistosoma, is one of the most significant neglected tropical diseases, affecting more than 200 million individuals worldwide and praziquantel is the only available drug to treat this disease.
Artemisia absinthium L.
and Tanacetum parthenium L.
are species popularly used as anthelmintics.
We investigated the in vitro schistosomicidal activity of crude extracts of A.
absinthium (AA) and T.
parthenium (TP) and their isolated compounds.
AA and TP, at 200 μg/mL, were active, causing 100% mortality of all adult worms.
Chromatographic fractionation of AA leads to isolation of artemetin and hydroxypelenolide, while santin, apigenin, and parthenolide were isolated from TP.
Artemetin, hydroxypelenolide, santin, and apigenin, at 100 μM, were inactive against adult worms.
Parthenolide (12.5 to 100 μM) caused 100% mortality, tegumental alterations, and reduction of motor activity of all adult worms of S.
mansoni, without affecting mammalian cells.
Confocal laser scanning microscopy showed tegumental morphological alterations and changes on the numbers of tubercles of S.
mansoni worms.
This report provides the first evidence for the in vitro activity of parthenolide against adult worms of S.
mansoni, opening the route to further schistosomicidal studies with this compound.
American Psychological Association (APA)
de Almeida, Luísa Maria Silveira& Aleixo de Carvalho, Lara Soares& Gazolla, Matheus Coutinho& Pinto, Pedro Luiz Silva& Silva, Marcos Paulo Nascimento da& de Moraes, Josué…[et al.]. 2016. Flavonoids and Sesquiterpene Lactones from Artemisia absinthium and Tanacetum parthenium against Schistosoma mansoni Worms. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104511
Modern Language Association (MLA)
de Almeida, Luísa Maria Silveira…[et al.]. Flavonoids and Sesquiterpene Lactones from Artemisia absinthium and Tanacetum parthenium against Schistosoma mansoni Worms. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1104511
American Medical Association (AMA)
de Almeida, Luísa Maria Silveira& Aleixo de Carvalho, Lara Soares& Gazolla, Matheus Coutinho& Pinto, Pedro Luiz Silva& Silva, Marcos Paulo Nascimento da& de Moraes, Josué…[et al.]. Flavonoids and Sesquiterpene Lactones from Artemisia absinthium and Tanacetum parthenium against Schistosoma mansoni Worms. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104511
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104511