Biologics for Targeting Inflammatory Cytokines, Clinical Uses, and Limitations
Joint Authors
Rider, Peleg
Carmi, Yaron
Cohen, Idan
Source
International Journal of Cell Biology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-19
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Proinflammatory cytokines are potent mediators of numerous biological processes and are tightly regulated in the body.
Chronic uncontrolled levels of such cytokines can initiate and derive many pathologies, including incidences of autoimmunity and cancer.
Therefore, therapies that regulate the activity of inflammatory cytokines, either by supplementation of anti-inflammatory recombinant cytokines or by neutralizing them by using blocking antibodies, have been extensively used over the past decades.
Over the past few years, new innovative biological agents for blocking and regulating cytokine activities have emerged.
Here, we review some of the most recent approaches of cytokine targeting, focusing on anti-TNF antibodies or recombinant TNF decoy receptor, recombinant IL-1 receptor antagonist (IL-1Ra) and anti-IL-1 antibodies, anti-IL-6 receptor antibodies, and TH17 targeting antibodies.
We discuss their effects as biologic drugs, as evaluated in numerous clinical trials, and highlight their therapeutic potential as well as emphasize their inherent limitations and clinical risks.
We suggest that while systemic blocking of proinflammatory cytokines using biological agents can ameliorate disease pathogenesis and progression, it may also abrogate the hosts defense against infections.
Moreover, we outline the rational need to develop new therapies, which block inflammatory cytokines only at sites of inflammation, while enabling their function systemically.
American Psychological Association (APA)
Rider, Peleg& Carmi, Yaron& Cohen, Idan. 2016. Biologics for Targeting Inflammatory Cytokines, Clinical Uses, and Limitations. International Journal of Cell Biology،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1105510
Modern Language Association (MLA)
Rider, Peleg…[et al.]. Biologics for Targeting Inflammatory Cytokines, Clinical Uses, and Limitations. International Journal of Cell Biology No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1105510
American Medical Association (AMA)
Rider, Peleg& Carmi, Yaron& Cohen, Idan. Biologics for Targeting Inflammatory Cytokines, Clinical Uses, and Limitations. International Journal of Cell Biology. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1105510
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1105510