Melatonin in Epilepsy: A New Mathematical Model of Diurnal Secretion
Joint Authors
Paprocka, Justyna
Kijonka, Marek
Pęcka, Marcin
Sokół, Maria
Source
International Journal of Endocrinology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-13
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Purpose.
The main objective of the study was to create a mathematical model that describes the melatonin circadian secretion and, then the functionality of the model was tested by a comparison of the melatonin secretions in children with and without epilepsy.
Material and Methods.
The patients were divided into the epilepsy group (EG, n = 52 ) and the comparison group (CG, n = 30 ).
The melatonin level was assessed by a radioimmunoassay method.
The diurnal melatonin secretion was described using a nonlinear least squares method.
Spearman’s rank correlation coefficient was chosen to estimate the dependence of the acquired data.
The model reproduces blood concentration profiles and its parameters were statistically analyzed using the Mann-Whitney-Wilcoxon test and logistic regression.
Results.
The correlation analysis performed for the EG and CG groups showed moderate correlations between age and the melatonin secretion model parameters.
Patients with epilepsy are characterized by an increased phase shift of melatonin release.
American Psychological Association (APA)
Paprocka, Justyna& Kijonka, Marek& Pęcka, Marcin& Sokół, Maria. 2016. Melatonin in Epilepsy: A New Mathematical Model of Diurnal Secretion. International Journal of Endocrinology،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1105867
Modern Language Association (MLA)
Paprocka, Justyna…[et al.]. Melatonin in Epilepsy: A New Mathematical Model of Diurnal Secretion. International Journal of Endocrinology No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1105867
American Medical Association (AMA)
Paprocka, Justyna& Kijonka, Marek& Pęcka, Marcin& Sokół, Maria. Melatonin in Epilepsy: A New Mathematical Model of Diurnal Secretion. International Journal of Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1105867
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1105867