Prognostic Value of Invasion, Markers of Proliferation, and Classification of Giant Pituitary Tumors, in a Georeferred Cohort in Brazil of 50 Patients, with a Long-Term Postoperative Follow-Up
Joint Authors
Motta, Lucilia Casulari Domingues
Zakir, Juliano Coelho de Oliveira
Rosa, José Wilson Corrêa
Rosa, João Willy Corrêa
Mello, Paulo Andrade de
Magalhães, Albino Verçosa de
Naves, Luciana Ansaneli
Source
International Journal of Endocrinology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-18
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Although some pituitary adenomas may have an aggressive behavior, the vast majority are benign.
There are still controversies about predictive factors regarding the biological behavior of these particular tumors.
This study evaluated potential markers of invasion and proliferation compared to current classification patterns and epidemiogeographical parameters.
The study included 50 patients, operated on for tumors greater than 30 mm, with a mean postoperative follow-up of 15.2 ± 4.8 years.
Pituitary magnetic resonance was used to evaluate regrowth, invasion, and extension to adjacent tissue.
Three tissue biomarkers were analyzed: p53, Ki-67, and c-erbB2.
Tumors were classified according to a combination of histological and radiological features, ranging from noninvasive and nonproliferative (grade 1A) to invasive-proliferative (grade 2B).
Tumors grades 2A and 2B represented 42% and 52%, respectively.
Ki-67 ( p = 0.23 ) and c-erbB2 ( p = 0.71 ) had no significant relation to tumor progression status.
P53 ( p = 0.003 ), parasellar invasion ( p = 0.03 ), and classification, grade 2B ( p = 0.01 ), were associated with worse clinical outcome.
Parasellar invasion prevails as strong predictive factor of tumor recurrence.
Severe suprasellar extension should be considered as invasion parameter and could impact prognosis.
No environmental factors or geographical cluster were associated with tumor behavior.
American Psychological Association (APA)
Zakir, Juliano Coelho de Oliveira& Motta, Lucilia Casulari Domingues& Rosa, José Wilson Corrêa& Rosa, João Willy Corrêa& Mello, Paulo Andrade de& Magalhães, Albino Verçosa de…[et al.]. 2016. Prognostic Value of Invasion, Markers of Proliferation, and Classification of Giant Pituitary Tumors, in a Georeferred Cohort in Brazil of 50 Patients, with a Long-Term Postoperative Follow-Up. International Journal of Endocrinology،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1106000
Modern Language Association (MLA)
Zakir, Juliano Coelho de Oliveira…[et al.]. Prognostic Value of Invasion, Markers of Proliferation, and Classification of Giant Pituitary Tumors, in a Georeferred Cohort in Brazil of 50 Patients, with a Long-Term Postoperative Follow-Up. International Journal of Endocrinology No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1106000
American Medical Association (AMA)
Zakir, Juliano Coelho de Oliveira& Motta, Lucilia Casulari Domingues& Rosa, José Wilson Corrêa& Rosa, João Willy Corrêa& Mello, Paulo Andrade de& Magalhães, Albino Verçosa de…[et al.]. Prognostic Value of Invasion, Markers of Proliferation, and Classification of Giant Pituitary Tumors, in a Georeferred Cohort in Brazil of 50 Patients, with a Long-Term Postoperative Follow-Up. International Journal of Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1106000
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1106000