The Role of Isotretinoin Therapy for Cushing’s Disease: Results of a Prospective Study
Joint Authors
Naves, Luciana Ansaneli
Vilar, Lucio
Albuquerque, José Luciano
Lyra, Ruy
Trovão Diniz, Erik
Rangel Filho, Frederico
Gadelha, Patrícia
Thé, Ana Carolina
Ibiapina, George Robson
Gomes, Barbara Sales
Santos, Vera
Melo da Fonseca, Maíra
Frasão Viana, Karoline
Lopes, Isis Gabriella
Araújo, Douglas
Source
International Journal of Endocrinology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
This prospective open trial aimed to evaluate the efficacy and safety of isotretinoin (13-cis-retinoic acid) in patients with Cushing’s disease (CD).
Methods.
Sixteen patients with CD and persistent or recurrent hypercortisolism after transsphenoidal surgery were given isotretinoin orally for 6–12 months.
The drug was started on 20 mg daily and the dosage was increased up to 80 mg daily if needed and tolerated.
Clinical, biochemical, and hormonal parameters were evaluated at baseline and monthly for 6–12 months.
Results.
Of the 16 subjects, 4% (25%) persisted with normal urinary free cortisol (UFC) levels at the end of the study.
UFC reductions of up to 52.1% were found in the rest.
Only patients with UFC levels below 2.5-fold of the upper limit of normal achieved sustained UFC normalization.
Improvements of clinical and biochemical parameters were also noted mostly in responsive patients.
Typical isotretinoin side-effects were experienced by 7 patients (43.7%), though they were mild and mostly transient.
We also observed that the combination of isotretinoin with cabergoline, in relatively low doses, may occasionally be more effective than either drug alone.
Conclusions.
Isotretinoin may be an effective and safe therapy for some CD patients, particularly those with mild hypercortisolism.
American Psychological Association (APA)
Vilar, Lucio& Albuquerque, José Luciano& Lyra, Ruy& Trovão Diniz, Erik& Rangel Filho, Frederico& Gadelha, Patrícia…[et al.]. 2016. The Role of Isotretinoin Therapy for Cushing’s Disease: Results of a Prospective Study. International Journal of Endocrinology،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1106003
Modern Language Association (MLA)
Vilar, Lucio…[et al.]. The Role of Isotretinoin Therapy for Cushing’s Disease: Results of a Prospective Study. International Journal of Endocrinology No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1106003
American Medical Association (AMA)
Vilar, Lucio& Albuquerque, José Luciano& Lyra, Ruy& Trovão Diniz, Erik& Rangel Filho, Frederico& Gadelha, Patrícia…[et al.]. The Role of Isotretinoin Therapy for Cushing’s Disease: Results of a Prospective Study. International Journal of Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1106003
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1106003