Insulin-Sensitizers, Polycystic Ovary Syndrome and Gynaecological Cancer Risk
Joint Authors
Appetecchia, Marialuisa
Lauretta, Rosa
Lanzolla, Giulia
Vici, Patrizia
Mariani, Luciano
Moretti, Costanzo
Source
International Journal of Endocrinology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-20
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Preclinical, early phase clinical trials and epidemiological evidence support the potential role of insulin-sensitizers in cancer prevention and treatment.
Insulin-sensitizers improve the metabolic and hormonal profile in PCOS patients and may also act as anticancer agents, especially in cancers associated with hyperinsulinemia and oestrogen dependent cancers.
Several lines of evidence support the protection against cancer exerted by dietary inositol, in particular inositol hexaphosphate.
Metformin, thiazolidinediones, and myoinositol postreceptor signaling may exhibit direct inhibitory effects on cancer cell growth.
AMPK, the main molecular target of metformin, is emerging as a target for cancer prevention and treatment.
PCOS may be correlated to an increased risk for developing ovarian and endometrial cancer (up to threefold).
Several studies have demonstrated an increase in mortality rate from ovarian cancer among overweight/obese PCOS women compared with normal weight women.
Long-term use of metformin has been associated with lower rates of ovarian cancer.
Considering the evidence supporting a higher risk of gynaecological cancer in PCOS women, we discuss the potential use of insulin-sensitizers as a potential tool for chemoprevention, hypothesizing a possible rationale through which insulin-sensitizers may inhibit tumourigenesis.
American Psychological Association (APA)
Lauretta, Rosa& Lanzolla, Giulia& Vici, Patrizia& Mariani, Luciano& Moretti, Costanzo& Appetecchia, Marialuisa. 2016. Insulin-Sensitizers, Polycystic Ovary Syndrome and Gynaecological Cancer Risk. International Journal of Endocrinology،Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1106037
Modern Language Association (MLA)
Lauretta, Rosa…[et al.]. Insulin-Sensitizers, Polycystic Ovary Syndrome and Gynaecological Cancer Risk. International Journal of Endocrinology No. 2016 (2016), pp.1-17.
https://search.emarefa.net/detail/BIM-1106037
American Medical Association (AMA)
Lauretta, Rosa& Lanzolla, Giulia& Vici, Patrizia& Mariani, Luciano& Moretti, Costanzo& Appetecchia, Marialuisa. Insulin-Sensitizers, Polycystic Ovary Syndrome and Gynaecological Cancer Risk. International Journal of Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1106037
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1106037