α-Amylase and α-Glucosidase Inhibitory Saponins from Polyscias fruticosa Leaves
Joint Authors
Hanh, Tran Thi Hong
Dang, Nguyen Hai
Dat, Nguyen Tien
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-30
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Three bisdesmosidic saponins 3-O-[β-D-glucopyranosyl-(1 → 4)-β-D-glucuronopyranosyl] oleanolic acid 28-O-β-D-glucopyranosyl ester (1), polyscioside D (2), and 3-O- { β -D-glucopyranosyl-(1 → 2)-[β-D-glucopyranosyl-(1 → 4)]-β-D- g l u c u r o n o p y r a n o s y l } oleanolic acid 28-O-β-D-glucopyranosyl-(1 → 2)-β-D-galactopyranosyl ester (3) were isolated from a methanol extract of Polyscias fruticosa (L.) Harms leaves.
Compound 1 was obtained as a main constituent and compound 3 was reported for the first time and named as polyscioside I.
Saponin 1 inhibited porcine pancreas α-amylase and yeast α-glucosidase activities while 2 and 3 were inactive.
Synergistic inhibitory effect on α-amylase was observed from the combination of low concentrations of 1 and acarbose.
The findings suggest the use of P.
fruticosa and its major saponin 1 for the prevention and treatment of diabetes and its complications.
American Psychological Association (APA)
Hanh, Tran Thi Hong& Dang, Nguyen Hai& Dat, Nguyen Tien. 2016. α-Amylase and α-Glucosidase Inhibitory Saponins from Polyscias fruticosa Leaves. Journal of Chemistry،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1107573
Modern Language Association (MLA)
Hanh, Tran Thi Hong…[et al.]. α-Amylase and α-Glucosidase Inhibitory Saponins from Polyscias fruticosa Leaves. Journal of Chemistry No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1107573
American Medical Association (AMA)
Hanh, Tran Thi Hong& Dang, Nguyen Hai& Dat, Nguyen Tien. α-Amylase and α-Glucosidase Inhibitory Saponins from Polyscias fruticosa Leaves. Journal of Chemistry. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1107573
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1107573