Incretin-Based Therapy for Prevention of Diabetic Vascular Complications
Author
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-31
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Diabetic vascular complications are the most common cause of mortality and morbidity worldwide, with numbers of affected individuals steadily increasing.
Diabetic vascular complications can be divided into two categories: macrovascular and microvascular complications.
Macrovascular complications include coronary artery disease and cerebrovascular disease, while microvascular complications include retinopathy and chronic kidney disease.
These complications result from metabolic abnormalities, including hyperglycemia, elevated levels of free fatty acids, and insulin resistance.
Multiple mechanisms have been proposed to mediate the adverse effects of these metabolic disorders on vascular tissues, including stimulation of protein kinase C signaling and activation of the polyol pathway by oxidative stress and inflammation.
Additionally, the loss of tissue-specific insulin signaling induced by hyperglycemia and toxic metabolites can induce cellular dysfunction and both macro- and microvascular complications characteristic of diabetes.
Despite these insights, few therapeutic methods are available for the management of diabetic complications.
Recently, incretin-based therapeutic agents, such as glucagon-like peptide-1 and dipeptidyl peptidase-4 inhibitors, have been reported to elicit vasotropic actions, suggesting a potential for effecting an actual reduction in diabetic vascular complications.
The present review will summarize the relationship between multiple adverse biological mechanisms in diabetes and putative incretin-based therapeutic interventions intended to prevent diabetic vascular complications.
American Psychological Association (APA)
Mima, Akira. 2015. Incretin-Based Therapy for Prevention of Diabetic Vascular Complications. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1107958
Modern Language Association (MLA)
Mima, Akira. Incretin-Based Therapy for Prevention of Diabetic Vascular Complications. Journal of Diabetes Research No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1107958
American Medical Association (AMA)
Mima, Akira. Incretin-Based Therapy for Prevention of Diabetic Vascular Complications. Journal of Diabetes Research. 2015. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1107958
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1107958