The IL-1β Receptor Antagonist SER140 Postpones the Onset of Diabetes in Female Nonobese Diabetic Mice
Joint Authors
Cucak, Helena
Hansen, Gitte
Vrang, Niels
Skarsfeldt, Torben
Steiness, Eva
Jelsing, Jacob
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-03
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The cytokine interleukin-1β (IL-1β) is known to stimulate proinflammatory immune responses and impair β-cell function and viability, all critical events in the pathogenesis of type 1 diabetes (T1D).
Here we evaluate the effect of SER140, a small peptide IL-1β receptor antagonist, on diabetes progression and cellular pancreatic changes in female nonobese diabetic (NOD) mice.
Eight weeks of treatment with SER140 reduced the incidence of diabetes by more than 50% compared with vehicle, decreased blood glucose, and increased plasma insulin.
Additionally, SER140 changed the endocrine and immune cells dynamics in the NOD mouse pancreas.
Together, the data suggest that SER140 treatment postpones the onset of diabetes in female NOD mice by interfering with IL-1β activated pathways.
American Psychological Association (APA)
Cucak, Helena& Hansen, Gitte& Vrang, Niels& Skarsfeldt, Torben& Steiness, Eva& Jelsing, Jacob. 2016. The IL-1β Receptor Antagonist SER140 Postpones the Onset of Diabetes in Female Nonobese Diabetic Mice. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1108242
Modern Language Association (MLA)
Cucak, Helena…[et al.]. The IL-1β Receptor Antagonist SER140 Postpones the Onset of Diabetes in Female Nonobese Diabetic Mice. Journal of Diabetes Research No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1108242
American Medical Association (AMA)
Cucak, Helena& Hansen, Gitte& Vrang, Niels& Skarsfeldt, Torben& Steiness, Eva& Jelsing, Jacob. The IL-1β Receptor Antagonist SER140 Postpones the Onset of Diabetes in Female Nonobese Diabetic Mice. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1108242
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108242