![](/images/graphics-bg.png)
The Polymorphism −308GA of Tumor Necrosis Factor-α Gene Modulates the Effect of Immunosuppressive Treatment in First Kidney Transplant Subjects Who Suffer an Acute Rejection
Joint Authors
Pérez-Flores, Isabel
Santiago, Jose Luis
Urcelay, Elena
Sánchez-Fructuoso, Ana Isabel
Valero, Rosalia
Moreno, Maria Angeles
Fernandez-Arquero, Miguel
Fernández-Pérez, Cristina
Source
Journal of Immunology Research
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-29
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The −308G/A SNP of tumor necrosis factor-alpha (TNF-α) gene affects TNF-α production.
As its impact on transplant outcome remains open to debate, we decided to genotype it in a cohort of transplant subjects.
A retrospective analysis of 439 first kidney recipients randomly divided into two subgroups (discovery and validation cohorts) was performed to identify the best predictors of acute rejection (AR).
The effect on transplant outcome was analyzed by an adjusted logistic regression model.
Carriers of the A allele, associated with elevated TNF-α production, presented a higher risk of AR (OR = 2.78; 95% CI = 1.40–5.51).
Logistic regression analyses for AR showed an interaction between the polymorphism and treatment with thymoglobulin (p-interaction = 0.03).
In recipients who did not receive thymoglobulin, carriers of A allele had higher risk of AR (OR = 4.05; 95% CI = 1.76–9.28).
Moreover, carriers of A allele not treated with thymoglobulin presented higher risk of AR than those who received thymoglobulin (OR = 13.74; 95% CI = 1.59–118.7).
The AUC of the model in the discovery cohort was 0.70 and in the validation cohort was 0.69.
Our findings indicate that the −308G/A TNF-α polymorphism is associated with AR risk and it modulates the effectiveness of thymoglobulin treatment.
This pharmacogenetic effect lets us propose this SNP as a useful predictor biomarker to tailor immunosuppressive regimens.
American Psychological Association (APA)
Sánchez-Fructuoso, Ana Isabel& Pérez-Flores, Isabel& Valero, Rosalia& Moreno, Maria Angeles& Fernandez-Arquero, Miguel& Urcelay, Elena…[et al.]. 2016. The Polymorphism −308GA of Tumor Necrosis Factor-α Gene Modulates the Effect of Immunosuppressive Treatment in First Kidney Transplant Subjects Who Suffer an Acute Rejection. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1108731
Modern Language Association (MLA)
Sánchez-Fructuoso, Ana Isabel…[et al.]. The Polymorphism −308GA of Tumor Necrosis Factor-α Gene Modulates the Effect of Immunosuppressive Treatment in First Kidney Transplant Subjects Who Suffer an Acute Rejection. Journal of Immunology Research No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1108731
American Medical Association (AMA)
Sánchez-Fructuoso, Ana Isabel& Pérez-Flores, Isabel& Valero, Rosalia& Moreno, Maria Angeles& Fernandez-Arquero, Miguel& Urcelay, Elena…[et al.]. The Polymorphism −308GA of Tumor Necrosis Factor-α Gene Modulates the Effect of Immunosuppressive Treatment in First Kidney Transplant Subjects Who Suffer an Acute Rejection. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1108731
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108731