Potential Involvement of Type I Interferon Signaling in Immunotherapy in Seasonal Allergic Rhinitis
Joint Authors
Mattson, Lina
Lentini, Antonio
Gawel, Danuta R.
Badam, Tejaswi V. S.
Benson, Mikael
Ledin, Torbjorn
Nestor, Colm E.
Gustafsson, Mika
Serra-Musach, Jordi
Bjorkander, Janne
Xiang, Zou
Zhang, Huan
Source
Journal of Immunology Research
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-19
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Specific immunotherapy (SIT) reverses the symptoms of seasonal allergic rhinitis (SAR) in most patients.
Recent studies report type I interferons shifting the balance between type I T helper cell (Th1) and type II T helper cells (Th2) towards Th2 dominance by inhibiting the differentiation of naive T cells into Th1 cells.
As SIT is thought to cause a shift towards Th1 dominance, we hypothesized that SIT would alter interferon type I signaling.
To test this, allergen and diluent challenged CD4+ T cells from healthy controls and patients from different time points were analyzed.
The initial experiments focused on signature genes of the pathway and found complex changes following immunotherapy, which were consistent with our hypothesis.
As interferon signaling involves multiple genes, expression profiling studies were performed, showing altered expression of the pathway.
These findings require validation in a larger group of patients in further studies.
American Psychological Association (APA)
Mattson, Lina& Lentini, Antonio& Gawel, Danuta R.& Badam, Tejaswi V. S.& Benson, Mikael& Ledin, Torbjorn…[et al.]. 2016. Potential Involvement of Type I Interferon Signaling in Immunotherapy in Seasonal Allergic Rhinitis. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1108811
Modern Language Association (MLA)
Mattson, Lina…[et al.]. Potential Involvement of Type I Interferon Signaling in Immunotherapy in Seasonal Allergic Rhinitis. Journal of Immunology Research No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1108811
American Medical Association (AMA)
Mattson, Lina& Lentini, Antonio& Gawel, Danuta R.& Badam, Tejaswi V. S.& Benson, Mikael& Ledin, Torbjorn…[et al.]. Potential Involvement of Type I Interferon Signaling in Immunotherapy in Seasonal Allergic Rhinitis. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1108811
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108811