Roles of Zinc Signaling in the Immune System
Joint Authors
Hojyo, Shintaro
Fukada, Toshiyuki
Source
Journal of Immunology Research
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-21, 21 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-31
Country of Publication
Egypt
No. of Pages
21
Main Subjects
Abstract EN
Zinc (Zn) is an essential micronutrient for basic cell activities such as cell growth, differentiation, and survival.
Zn deficiency depresses both innate and adaptive immune responses.
However, the precise physiological mechanisms of the Zn-mediated regulation of the immune system have been largely unclear.
Zn homeostasis is tightly controlled by the coordinated activity of Zn transporters and metallothioneins, which regulate the transport, distribution, and storage of Zn.
There is growing evidence that Zn behaves like a signaling molecule, facilitating the transduction of a variety of signaling cascades in response to extracellular stimuli.
In this review, we highlight the emerging functional roles of Zn and Zn transporters in immunity, focusing on how crosstalk between Zn and immune-related signaling guides the normal development and function of immune cells.
American Psychological Association (APA)
Hojyo, Shintaro& Fukada, Toshiyuki. 2016. Roles of Zinc Signaling in the Immune System. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-21.
https://search.emarefa.net/detail/BIM-1108853
Modern Language Association (MLA)
Hojyo, Shintaro& Fukada, Toshiyuki. Roles of Zinc Signaling in the Immune System. Journal of Immunology Research No. 2016 (2016), pp.1-21.
https://search.emarefa.net/detail/BIM-1108853
American Medical Association (AMA)
Hojyo, Shintaro& Fukada, Toshiyuki. Roles of Zinc Signaling in the Immune System. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-21.
https://search.emarefa.net/detail/BIM-1108853
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108853