Enhanced Stem Cell Osteogenic Differentiation by Bioactive Glass Functionalized Graphene Oxide Substrates
Joint Authors
Zhang, Xuehui
Shen, Yang
Meng, Song
Dai, Xiaohan
Wei, Yan
Mo, Xiaoju
Liu, Xing
Cai, Qing
Liu, Yun
Hu, Zhewen
Liang, Xu-Deng
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-14
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
An unmet need in engineered bone regeneration is to develop scaffolds capable of manipulating stem cells osteogenesis.
Graphene oxide (GO) has been widely used as a biomaterial for various biomedical applications.
However, it remains challenging to functionalize GO as ideal platform for specifically directing stem cell osteogenesis.
Herein, we report facile functionalization of GO with dopamine and subsequent bioactive glass (BG) to enhance stem cell adhesion, spreading, and osteogenic differentiation.
On the basis of graphene, we obtained dopamine functionalized graphene oxide/bioactive glass (DGO/BG) hybrid scaffolds containing different content of DGO by loading BG nanoparticles on graphene oxide surface using sol-gel method.
To enhance the dispersion stability and facilitate subsequent nucleation of BG in GO, firstly, dopamine (DA) was used to modify GO.
Then, the modified GO was functionalized with bioactive glass (BG) using sol-gel method.
The adhesion, spreading, and osteoinductive effects of DGO/BG scaffold on rat bone marrow mesenchymal stem cells (rBMSCs) were evaluated.
DGO/BG hybrid scaffolds with different content of DGO could influence rBMSCs’ behavior.
The highest expression level of osteogenic markers suggests that the DGO/BG hybrid scaffolds have great potential or elicit desired bone reparative outcome.
American Psychological Association (APA)
Mo, Xiaoju& Wei, Yan& Zhang, Xuehui& Cai, Qing& Shen, Yang& Dai, Xiaohan…[et al.]. 2016. Enhanced Stem Cell Osteogenic Differentiation by Bioactive Glass Functionalized Graphene Oxide Substrates. Journal of Nanomaterials،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1109246
Modern Language Association (MLA)
Mo, Xiaoju…[et al.]. Enhanced Stem Cell Osteogenic Differentiation by Bioactive Glass Functionalized Graphene Oxide Substrates. Journal of Nanomaterials No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1109246
American Medical Association (AMA)
Mo, Xiaoju& Wei, Yan& Zhang, Xuehui& Cai, Qing& Shen, Yang& Dai, Xiaohan…[et al.]. Enhanced Stem Cell Osteogenic Differentiation by Bioactive Glass Functionalized Graphene Oxide Substrates. Journal of Nanomaterials. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1109246
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1109246