Inhibition of Intestinal α-Glucosidase and Glucose Absorption by Feruloylated Arabinoxylan Mono- and Oligosaccharides from Corn Bran and Wheat Aleurone
Joint Authors
Malunga, Lovemore Nkhata
Eck, Peter
Beta, Trust
Source
Journal of Nutrition and Metabolism
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The effect of feruloylated arabinoxylan mono- and oligosaccharides (FAXmo) on mammalian α-glucosidase and glucose transporters was investigated using human Caco-2 cells, rat intestinal acetone powder, and Xenopus laevis oocytes.
The isolated FAXmo from wheat aleurone and corn bran were identified to have degree of polymerization (DP) of 4 and 1, respectively, by HPLC-MS.
Both FAXmo extracts were effective inhibitors of sucrase and maltase functions of the α-glucosidase.
The IC50 for FAXmo extracts on Caco-2 cells and rat intestinal α-glucosidase was 1.03–1.65 mg/mL and 2.6–6.5 mg/mL, respectively.
Similarly, glucose uptake in Caco-2 cells was inhibited up to 40%.
The inhibitory effect of FAXmo was dependent on their ferulic acid (FA) content ( R = 0.95).
Sodium independent glucose transporter 2 (GLUT2) activity was completely inhibited by FAXmo in oocytes injected to express GLUT2.
Our results suggest that ferulic acid and feruloylated arabinoxylan mono-/oligosaccharides have potential for use in diabetes management.
American Psychological Association (APA)
Malunga, Lovemore Nkhata& Eck, Peter& Beta, Trust. 2016. Inhibition of Intestinal α-Glucosidase and Glucose Absorption by Feruloylated Arabinoxylan Mono- and Oligosaccharides from Corn Bran and Wheat Aleurone. Journal of Nutrition and Metabolism،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1109572
Modern Language Association (MLA)
Malunga, Lovemore Nkhata…[et al.]. Inhibition of Intestinal α-Glucosidase and Glucose Absorption by Feruloylated Arabinoxylan Mono- and Oligosaccharides from Corn Bran and Wheat Aleurone. Journal of Nutrition and Metabolism No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1109572
American Medical Association (AMA)
Malunga, Lovemore Nkhata& Eck, Peter& Beta, Trust. Inhibition of Intestinal α-Glucosidase and Glucose Absorption by Feruloylated Arabinoxylan Mono- and Oligosaccharides from Corn Bran and Wheat Aleurone. Journal of Nutrition and Metabolism. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1109572
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1109572