Evaluation of the Anti-Inflammatory Effect of Locally Delivered Vitamin C in the Treatment of Persistent Gingival Inflammation: Clinical and Histopathological Study

Abstract EN

Objective.

The purpose of this study is to investigate the role and efficiency of the locally injected vitamin C in the treatment of persistent gingival inflammation.

Design.

Twenty adult patients with persistent chronic gingival inflammation were included in this study.

The same dose of sterile vitamin C was injected in gingival tissues after the completion of phase I therapy.

Gingival biopsies were taken after total resolution of inflammation.

The specimens were examined histologically, using H&E stain.

Results.

Clinical evaluation revealed great improvement of the injected sites with recall visits.

Histopathological results revealed marked decrease in inflammatory cells and epithelial thickness and a higher number of newly formed subbasal capillaries.

Conclusions.

Vitamin C is an effective adjunctive treatment in reducing various degrees of chronic gingival inflammation.