Effect of the Lipoxygenase Inhibitor Baicalein on Muscles in Ovariectomized Rats
Joint Authors
Saul, D.
Kling, J. H.
Kosinsky, R. L.
Hoffmann, D. B.
Komrakova, M.
Wicke, M.
Menger, B.
Sehmisch, S.
Source
Journal of Nutrition and Metabolism
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-05
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Sarcopenia, a loss of muscle mass accompanying osteoporosis, leads to falls and fall-related injuries.
Baicalein, as a phytochemical agent, has an antioxidative and anti-inflammatory effect in muscle.
In this study, sixty-one female Sprague Dawley rats were divided into five groups: four groups were ovariectomized (OVX) and one control group was nonovariectomized (NON-OVX).
Eight weeks after ovariectomy, three disparate concentrations (1 mg/kg body weight (BW), 10 mg/kg BW, and 100 mg/kg BW) of baicalein were applied subcutaneously daily in three OVX groups.
Mm.
soleus, gastrocnemius, and longissimus were extracted; their diameter, area, relation to body, and muscle weights as well as number of capillaries per fibre were recorded.
In Mm.
soleus and gastrocnemius, the baicalein effect (increasing number of capillaries per fibre) was proportional to the dose applied.
The fibre diameters and area under baicalein treatment were significantly greater compared to OVX and NON-OVX groups.
In M.
longissimus, we observed a shift to type IIa fibres.
Serum creatine kinase levels were significantly lower in highest baicalein concentration group.
We conclude that baicalein can stimulate angiogenesis, though not fibre type-specific, in skeletal muscle and reduce the estrogen-related loss of fibre diameter and area in the skeletal muscle in rats.
Therefore, a protective effect of baicalein on muscle cells can be assumed.
American Psychological Association (APA)
Saul, D.& Kling, J. H.& Kosinsky, R. L.& Hoffmann, D. B.& Komrakova, M.& Wicke, M.…[et al.]. 2016. Effect of the Lipoxygenase Inhibitor Baicalein on Muscles in Ovariectomized Rats. Journal of Nutrition and Metabolism،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1109587
Modern Language Association (MLA)
Saul, D.…[et al.]. Effect of the Lipoxygenase Inhibitor Baicalein on Muscles in Ovariectomized Rats. Journal of Nutrition and Metabolism No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1109587
American Medical Association (AMA)
Saul, D.& Kling, J. H.& Kosinsky, R. L.& Hoffmann, D. B.& Komrakova, M.& Wicke, M.…[et al.]. Effect of the Lipoxygenase Inhibitor Baicalein on Muscles in Ovariectomized Rats. Journal of Nutrition and Metabolism. 2016. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1109587
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1109587