Effects of a Multispecies Probiotic Mixture on Glycemic Control and Inflammatory Status in Women with Gestational Diabetes: A Randomized Controlled Clinical Trial
Joint Authors
Jafarnejad, Sadegh
Saremi, Sadaf
Jafarnejad, Farzan
Arab, Arman
Source
Journal of Nutrition and Metabolism
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
This trial aims to examine the effects of a Probiotic Mixture (VSL#3) on glycemic status and inflammatory markers, in women with GDM.
Materials and Methods.
Over a period of 8 weeks, 82 women with gestational diabetes were randomly assigned to either an intervention group ( n = 41 ) which were given VSL#3 capsule or to a control group which were given placebo capsule ( n = 41 ).
Fasting plasma glucose, homeostatic model assessment of insulin resistance, glycosylated hemoglobin, high-sensitivity C-reactive protein, tumor necrosis factor-α, interleukin-6, Interferon gamma, and interleukin-10 were measured before and after the intervention.
Results.
After 8 wk of supplementation FPG, HbA1c, HOMA-IR, and insulin levels remained unchanged in the probiotic and placebo groups.
The comparison between the two groups showed no significant differences with FPG and HbA1c, but there were significant differences in insulin levels and HOMA-IR ( 16.6 ± 5.9 ; 3.7 ± 1.5 , resp.).
Unlike the levels of IFN-g ( 19.21 ± 16.6 ), there was a significant decrease in levels of IL-6 ( 3.81 ± 0.7 ), TNF-α ( 3.10 ± 1.1 ), and hs-CRP ( 4927.4 ± 924.6 ).
No significant increase was observed in IL-10 ( 3.11 ± 5.7 ) in the intervention group as compared with the control group.
Conclusions.
In women with GDM, supplementation with probiotics (VSL#3) may help to modulate some inflammatory markers and may have benefits on glycemic control.
American Psychological Association (APA)
Jafarnejad, Sadegh& Saremi, Sadaf& Jafarnejad, Farzan& Arab, Arman. 2016. Effects of a Multispecies Probiotic Mixture on Glycemic Control and Inflammatory Status in Women with Gestational Diabetes: A Randomized Controlled Clinical Trial. Journal of Nutrition and Metabolism،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1109594
Modern Language Association (MLA)
Jafarnejad, Sadegh…[et al.]. Effects of a Multispecies Probiotic Mixture on Glycemic Control and Inflammatory Status in Women with Gestational Diabetes: A Randomized Controlled Clinical Trial. Journal of Nutrition and Metabolism No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1109594
American Medical Association (AMA)
Jafarnejad, Sadegh& Saremi, Sadaf& Jafarnejad, Farzan& Arab, Arman. Effects of a Multispecies Probiotic Mixture on Glycemic Control and Inflammatory Status in Women with Gestational Diabetes: A Randomized Controlled Clinical Trial. Journal of Nutrition and Metabolism. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1109594
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1109594