Serum Metabolomic Response to Long-Term Supplementation with all-rac-α-Tocopheryl Acetate in a Randomized Controlled Trial
Joint Authors
Mondul, Alison M.
Moore, Steven C.
Weinstein, Stephanie J.
Evans, Anne M.
Karoly, Edward D.
Männistö, Satu
Sampson, Joshua N.
Albanes, Demetrius
Source
Journal of Nutrition and Metabolism
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-20
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
The Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study, a randomized controlled cancer prevention trial, showed a 32% reduction in prostate cancer incidence in response to vitamin E supplementation.
Two other trials were not confirmatory, however.
Objective.
We compared the change in serum metabolome of the ATBC Study participants randomized to receive vitamin E to those who were not by randomly selecting 50 men from each of the intervention groups (50 mg/day all-rac-α-tocopheryl acetate (ATA), 20 mg/day β-carotene, both, placebo).
Methods.
Metabolomic profiling was conducted on baseline and follow-up fasting serum (Metabolon, Inc.).
Results.
After correction for multiple comparisons, five metabolites were statistically significantly altered (β is the change in metabolite level expressed as number of standard deviations on the log scale): α-CEHC sulfate (β=1.51, p=1.45×10-38), α-CEHC glucuronide (β=1.41, p=1.02×10-31), α-tocopherol (β=0.97, p=2.22×10-13), γ-tocopherol (β=-0.90, p=1.76×10-11), and β-tocopherol (β=-0.73, p=9.40×10-8).
Glutarylcarnitine, beta-alanine, ornithine, and N6-acetyllysine were also decreased by ATA supplementation (β range 0.40 to −0.36), but not statistically significantly.
Conclusions.
Comparison of the observed metabolite alterations resulting from ATA supplementation to those in other vitamin E trials of different populations, dosages, or formulations may shed light on the apparently discordant vitamin E-prostate cancer risk findings.
American Psychological Association (APA)
Mondul, Alison M.& Moore, Steven C.& Weinstein, Stephanie J.& Evans, Anne M.& Karoly, Edward D.& Männistö, Satu…[et al.]. 2016. Serum Metabolomic Response to Long-Term Supplementation with all-rac-α-Tocopheryl Acetate in a Randomized Controlled Trial. Journal of Nutrition and Metabolism،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1109597
Modern Language Association (MLA)
Mondul, Alison M.…[et al.]. Serum Metabolomic Response to Long-Term Supplementation with all-rac-α-Tocopheryl Acetate in a Randomized Controlled Trial. Journal of Nutrition and Metabolism No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1109597
American Medical Association (AMA)
Mondul, Alison M.& Moore, Steven C.& Weinstein, Stephanie J.& Evans, Anne M.& Karoly, Edward D.& Männistö, Satu…[et al.]. Serum Metabolomic Response to Long-Term Supplementation with all-rac-α-Tocopheryl Acetate in a Randomized Controlled Trial. Journal of Nutrition and Metabolism. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1109597
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1109597