Hypoxia-Inducible Factor-1α Expression in Indonesian Laryngeal Squamous Cell Carcinoma Patients
Joint Authors
Surono, Agus
Priyanto, Priyanto
Indrasari, Sagung Rai
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-01
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Objectives.
This research aimed to determine the association between hypoxia-inducible factor-1α (HIF-1α) expression and laryngeal squamous cell carcinoma clinical stage.
Methods.
We retrospectively analyzed paraffin-embedded tissue from 47 laryngeal squamous cell carcinoma (LSCC) patients from 2011 to 2014.
HIF-1α expression was analyzed by immunohistochemistry using an anti-HIF-1α mouse monoclonal antibody.
The association between HIF-1α expression and clinical stage was analyzed using the chi square test.
Results.
The glottis was the predominant site of laryngeal squamous cell carcinoma occurrence, and 43/47 (91.5%) patients presented at an advanced stage.
Of the advanced stage patients, 27/43 stained positive for HIF-1α expression and 16/43 stained negative.
Of the early stage patients, 2/4 stained positive for HIF-1α expression and 2/4 stained negative.
Statistical analysis did not demonstrate significant association of HIF-1α expression.
Conclusion.
There was no statistically significant association between HIF-1α expression and the clinical stage or histological differentiation of LSCC.
American Psychological Association (APA)
Surono, Agus& Priyanto, Priyanto& Indrasari, Sagung Rai. 2016. Hypoxia-Inducible Factor-1α Expression in Indonesian Laryngeal Squamous Cell Carcinoma Patients. Journal of Oncology،Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1109693
Modern Language Association (MLA)
Surono, Agus…[et al.]. Hypoxia-Inducible Factor-1α Expression in Indonesian Laryngeal Squamous Cell Carcinoma Patients. Journal of Oncology No. 2016 (2016), pp.1-4.
https://search.emarefa.net/detail/BIM-1109693
American Medical Association (AMA)
Surono, Agus& Priyanto, Priyanto& Indrasari, Sagung Rai. Hypoxia-Inducible Factor-1α Expression in Indonesian Laryngeal Squamous Cell Carcinoma Patients. Journal of Oncology. 2016. Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1109693
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1109693