Hypoxia-Inducible Factor-1α Expression in Indonesian Laryngeal Squamous Cell Carcinoma Patients

Abstract EN

Objectives.

This research aimed to determine the association between hypoxia-inducible factor-1α (HIF-1α) expression and laryngeal squamous cell carcinoma clinical stage.

Methods.

We retrospectively analyzed paraffin-embedded tissue from 47 laryngeal squamous cell carcinoma (LSCC) patients from 2011 to 2014.

HIF-1α expression was analyzed by immunohistochemistry using an anti-HIF-1α mouse monoclonal antibody.

The association between HIF-1α expression and clinical stage was analyzed using the chi square test.

Results.

The glottis was the predominant site of laryngeal squamous cell carcinoma occurrence, and 43/47 (91.5%) patients presented at an advanced stage.

Of the advanced stage patients, 27/43 stained positive for HIF-1α expression and 16/43 stained negative.

Of the early stage patients, 2/4 stained positive for HIF-1α expression and 2/4 stained negative.

Statistical analysis did not demonstrate significant association of HIF-1α expression.

Conclusion.

There was no statistically significant association between HIF-1α expression and the clinical stage or histological differentiation of LSCC.