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Altered Brain Glucose Consumption in Cogan’s Syndrome
Joint Authors
Rubino, Pierangela
Mora, Paolo
Gandolfi, Stefano A.
Ruffini, Livia
Ghetti, Caterina
Ghirardini, Stella
Scarlattei, Maura
Baldari, Giorgio
Cidda, Carla
Orsoni, Jelka G.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-06
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Purpose.
Prospective, controlled cohort study to investigate possible alterations in brain glucose metabolism (CMRglc) in patients with Cogan’s syndrome (CS).
Patients and Methods.
Functional mapping of the CMRglc was obtained by quantitative molecular imaging positron emission tomography, combined with computed tomography (FDG-PET/CT).
The patients were divided into three clinical groups: typical CS; atypical CS (ACS); autoimmune inner ear disease (AIED).
The unmatched control group (CG) consisted of subjects requiring FDG-PET/CT for an extracranial pathology.
Statistical mapping searched areas of significant glucose hypometabolism in all the affected patients (DG) and in each clinical subgroup.
The results were compared with those of the CG.
Results.
44 patients were enrolled (DG) and assigned to the three study groups: 8 patients to the CS group; 21 patients to the ACS group; and 15 to the AIED group.
Sixteen subjects formed the CG group.
Areas of significant brain glucose hypometabolism were identified in all the study groups, with the largest number and extension in the DG and CS.
Conclusions.
This study revealed areas of significantly altered CMRglc in patients with CS (any subform) without neurologic complains and normal conventional neuroimaging.
Our results suggest that FDG-PET/CT may represent a very useful tool for the global assessment of patients with Cogan’s syndrome.
American Psychological Association (APA)
Mora, Paolo& Ruffini, Livia& Ghetti, Caterina& Ghirardini, Stella& Scarlattei, Maura& Baldari, Giorgio…[et al.]. 2016. Altered Brain Glucose Consumption in Cogan’s Syndrome. Journal of Ophthalmology،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1109920
Modern Language Association (MLA)
Mora, Paolo…[et al.]. Altered Brain Glucose Consumption in Cogan’s Syndrome. Journal of Ophthalmology No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1109920
American Medical Association (AMA)
Mora, Paolo& Ruffini, Livia& Ghetti, Caterina& Ghirardini, Stella& Scarlattei, Maura& Baldari, Giorgio…[et al.]. Altered Brain Glucose Consumption in Cogan’s Syndrome. Journal of Ophthalmology. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1109920
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1109920