Impact of Indocyanine Green Concentration, Exposure Time, and Degree of Dissolution in Creating Toxic Anterior Segment Syndrome: Evaluation in a Rabbit Model
Joint Authors
Auffarth, Gerd U.
Khoramnia, Ramin
Tandogan, Tamer
Young Choi, Chul
Koss, Michael J.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-12
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Purpose.
To investigate the role of indocyanine green (ICG) dye as a causative material of toxic anterior segment syndrome (TASS) in an experimental rabbit model.
Method.
Eight eyes of four rabbits were allocated to this study.
Capsular staining was performed using ICG dye, after which the anterior chamber was irrigated with a balanced salt solution.
The effects of different concentrations (control, 0.25, 0.5, and 1.0%), exposure times (10 and 60 seconds), and the degree of dissolution (differently vortexed) were investigated.
The analysis involved anterior segment photography, ultrasound pachymetry, prostaglandin assay (PGE2 Parameter Assay, R&D systems, Inc.), and scanning electron microscopy of each iris.
Result.
There was no reaction in the control eye.
A higher aqueous level of PGE2 and more severe inflammatory reaction were observed in cases of eyes with higher concentration, longer exposure time, and poorly dissolved dye.
Additionally, scanning electron microscopy revealed larger and coarser ICG particles.
Conclusion.
TASS occurrence may be associated with the concentration, exposure time, and degree of dissolution of ICG dye during cataract surgery.
American Psychological Association (APA)
Tandogan, Tamer& Khoramnia, Ramin& Auffarth, Gerd U.& Koss, Michael J.& Young Choi, Chul. 2016. Impact of Indocyanine Green Concentration, Exposure Time, and Degree of Dissolution in Creating Toxic Anterior Segment Syndrome: Evaluation in a Rabbit Model. Journal of Ophthalmology،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1109942
Modern Language Association (MLA)
Tandogan, Tamer…[et al.]. Impact of Indocyanine Green Concentration, Exposure Time, and Degree of Dissolution in Creating Toxic Anterior Segment Syndrome: Evaluation in a Rabbit Model. Journal of Ophthalmology No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1109942
American Medical Association (AMA)
Tandogan, Tamer& Khoramnia, Ramin& Auffarth, Gerd U.& Koss, Michael J.& Young Choi, Chul. Impact of Indocyanine Green Concentration, Exposure Time, and Degree of Dissolution in Creating Toxic Anterior Segment Syndrome: Evaluation in a Rabbit Model. Journal of Ophthalmology. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1109942
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1109942