Epstein-Barr Virus-Induced Gene 3 (EBI3) Blocking Leads to Induce Antitumor Cytotoxic T Lymphocyte Response and Suppress Tumor Growth in Colorectal Cancer by Bidirectional Reciprocal-Regulation STAT3 Signaling Pathway
Joint Authors
Liang, Yanfang
Chen, Qianqian
Du, Wenjing
Chen, Can
Li, Feifei
Yang, Jingying
Peng, Jianyu
Kang, Dongping
Lin, Bihua
Chai, Xingxing
Zhou, Keyuan
Zeng, Jincheng
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-10
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Epstein-Barr virus-induced gene 3 (EBI3) is a member of the interleukin-12 (IL-12) family structural subunit and can form a heterodimer with IL-27p28 and IL-12p35 subunit to build IL-27 and IL-35, respectively.
However, IL-27 stimulates whereas IL-35 inhibits antitumor T cell responses.
To date, little is known about the role of EBI3 in tumor microenvironment.
In this study, firstly we assessed EBI3, IL-27p28, IL-12p35, gp130, and p-STAT3 expression with clinicopathological parameters of colorectal cancer (CRC) tissues; then we evaluated the antitumor T cell responses and tumor growth with a EBI3 blocking peptide.
We found that elevated EBI3 may be associated with IL-12p35, gp130, and p-STAT3 to promote CRC progression.
EBI3 blocking peptide promoted antitumor cytotoxic T lymphocyte (CTL) response by inducing Granzyme B, IFN-γ production, and p-STAT3 expression and inhibited CRC cell proliferation and tumor growth to associate with suppressing gp130 and p-STAT3 expression.
Taken together, these results suggest that EBI3 may mediate a bidirectional reciprocal-regulation STAT3 signaling pathway to assist the tumor escape immune surveillance in CRC.
American Psychological Association (APA)
Liang, Yanfang& Chen, Qianqian& Du, Wenjing& Chen, Can& Li, Feifei& Yang, Jingying…[et al.]. 2016. Epstein-Barr Virus-Induced Gene 3 (EBI3) Blocking Leads to Induce Antitumor Cytotoxic T Lymphocyte Response and Suppress Tumor Growth in Colorectal Cancer by Bidirectional Reciprocal-Regulation STAT3 Signaling Pathway. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1111004
Modern Language Association (MLA)
Liang, Yanfang…[et al.]. Epstein-Barr Virus-Induced Gene 3 (EBI3) Blocking Leads to Induce Antitumor Cytotoxic T Lymphocyte Response and Suppress Tumor Growth in Colorectal Cancer by Bidirectional Reciprocal-Regulation STAT3 Signaling Pathway. Mediators of Inflammation No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1111004
American Medical Association (AMA)
Liang, Yanfang& Chen, Qianqian& Du, Wenjing& Chen, Can& Li, Feifei& Yang, Jingying…[et al.]. Epstein-Barr Virus-Induced Gene 3 (EBI3) Blocking Leads to Induce Antitumor Cytotoxic T Lymphocyte Response and Suppress Tumor Growth in Colorectal Cancer by Bidirectional Reciprocal-Regulation STAT3 Signaling Pathway. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1111004
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111004