Role of Transforming Growth Factor-β1 and Smads Signaling Pathway in Intrauterine Adhesion
Joint Authors
Sayed, Ali Sheikh Md
Salma, Umme
Xue, Min
Xu, Dabao
Guan, Xiaoming
Xu, Bin
Zhang, Aiqian
Huang, Lihua
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-21
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The aim of the study was to evaluate the role of Smad3, Smad7, and TGF-β1 in intrauterine adhesion (IUA) patients and experimental rabbit models.
60 IUA patients, 30 control participants, and 18 female rabbits were enrolled in this study.
We found that the plasma concentrations and protein expressions of TGF-β1 were significantly increased in patients and experimental rabbits compared to those in controls (P<0.05).
Furthermore, the mRNA and protein expression levels of Smad3 were significantly elevated, while Smad7 level was markedly decreased in the patients and experimental rabbits compared with controls (P<0.05).
This altered ratio recommended that IUA was positively correlated to the mRNA and protein expression levels of Smad3, Smad7, and TGF-β1 in blood and uterine tissue.
Moreover, we used the specific inhibitor of Smad3 (SIS3) in experimental rabbit.
SIS3 obviously reduced the mRNA and protein expression of smad3 and TGF-β1, while it increased Smad7 expression in the treatment groups as compared with IUA rabbits (P<0.05).
Our study suggested that TGF-β1/Smad3/smad7 is a major pathway which plays an important role in the regulation of the IUA and specific inhibitor of Smad3 (SIS3) may provide a new therapeutic strategy for IUA.
American Psychological Association (APA)
Salma, Umme& Xue, Min& Sayed, Ali Sheikh Md& Guan, Xiaoming& Xu, Bin& Zhang, Aiqian…[et al.]. 2016. Role of Transforming Growth Factor-β1 and Smads Signaling Pathway in Intrauterine Adhesion. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1111053
Modern Language Association (MLA)
Salma, Umme…[et al.]. Role of Transforming Growth Factor-β1 and Smads Signaling Pathway in Intrauterine Adhesion. Mediators of Inflammation No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1111053
American Medical Association (AMA)
Salma, Umme& Xue, Min& Sayed, Ali Sheikh Md& Guan, Xiaoming& Xu, Bin& Zhang, Aiqian…[et al.]. Role of Transforming Growth Factor-β1 and Smads Signaling Pathway in Intrauterine Adhesion. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1111053
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111053