Elevated Plasma Level of Interferon-λ1 in Chronic Spontaneous Urticaria: Upregulated Expression in CD8+ and Epithelial Cells and Induction of Inflammatory Cell Accumulation
Joint Authors
He, Shaoheng
Wang, S. F.
Gao, X. Q.
Xu, Y. N.
Li, D. N.
Wang, H. Y.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-30
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Interferon- (IFN-) λ1 is regarded as a potent bio-active molecule in innate immunity.
However, little is known about its role in chronic spontaneous urticaria (CSU).
We therefore investigated expression of IFN-λ1 in CSU, its cellular location, and its influence on inflammatory cell accumulation by using flow cytometry analysis, skin tissue dispersion, immunohistochemical stain, and a mouse peritoneal inflammation model.
The results showed that level of IFN-λ1 was 2.0-fold higher in plasma of the patients with CSU than the level in healthy control (HC) subjects.
Among leukocytes examined, only CD8+ T cells expressed more IFN-λ1 in CSU blood.
Double labeling immunohistochemical staining revealed that IFN-λ1+ inflammatory cells such as mast cells, eosinophils, B cells, neutrophils, and macrophages were mainly located in dermis, whereas epidermis tissue highly expressed IFN-λ1.
IFN-λ1 induced a dose-dependent increase in number of eosinophils, lymphocytes, mast cells, macrophages, and neutrophils in the peritoneum of mice at 6 h following injection, which was inhibited by pretreatment of the animals with anti-intercellular adhesion molecule- (ICAM-) 1 and/or anti-L-selectin antibodies.
In conclusion, IFN-λ1 is likely to play a role in the pathogenesis of CSU.
Blocking IFN-λ1 production may help to reduce the accumulation of inflammatory cells in the involved CSU skin.
American Psychological Association (APA)
Wang, S. F.& Gao, X. Q.& Xu, Y. N.& Li, D. N.& Wang, H. Y.& He, Shaoheng. 2016. Elevated Plasma Level of Interferon-λ1 in Chronic Spontaneous Urticaria: Upregulated Expression in CD8+ and Epithelial Cells and Induction of Inflammatory Cell Accumulation. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1111083
Modern Language Association (MLA)
Wang, S. F.…[et al.]. Elevated Plasma Level of Interferon-λ1 in Chronic Spontaneous Urticaria: Upregulated Expression in CD8+ and Epithelial Cells and Induction of Inflammatory Cell Accumulation. Mediators of Inflammation No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1111083
American Medical Association (AMA)
Wang, S. F.& Gao, X. Q.& Xu, Y. N.& Li, D. N.& Wang, H. Y.& He, Shaoheng. Elevated Plasma Level of Interferon-λ1 in Chronic Spontaneous Urticaria: Upregulated Expression in CD8+ and Epithelial Cells and Induction of Inflammatory Cell Accumulation. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1111083
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111083