Blockade of Wntβ-Catenin Pathway Aggravated Silica-Induced Lung Inflammation through Tregs Regulation on Th Immune Responses
Joint Authors
Chen, Ying
Dai, Wujing
Li, Chao
Liu, Fangwei
Lu, Yiping
Lu, Xiaowei
Du, Sitong
Weng, Dong
Chen, Jie
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-16
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
CD4+ T cells play an important role in regulating silica-induced inflammation and fibrosis.
Recent studies showed that Wnt/β-catenin pathway could modulate the function and the differentiation of CD4+ T cells.
Therefore, Wnt/β-catenin pathway may participate in the development and progress of silicosis.
To investigate the role of Wnt/β-catenin pathway, we used lentivirus expressing β-catenin shRNA to block the Wnt/β-catenin pathway by intratracheal instillation to the mice model of silicosis.
Treatment of lentivirus could significantly aggravate the silica-induced lung inflammation and attenuated the fibrosis at the late stage.
By analyzing CD4+ T cells, we found that blockade of Wnt/β-catenin pathway suppressed regulatory T cells (Tregs).
Reciprocally, enhanced Th17 response was responsible for the further accumulation of neutrophils and production of proinflammatory cytokines.
In addition, blockade of Wnt/β-catenin pathway delayed the Th1/Th2 polarization by inhibiting Tregs and Th2 response.
These results indicated that Wnt/β-catenin pathway could regulate Tregs to modulate Th immune response, which finally altered the pathological character of silicosis.
Our study suggested that Wnt/β-catenin pathway might be a potential target to treat the silica-induced inflammation and fibrosis.
American Psychological Association (APA)
Dai, Wujing& Liu, Fangwei& Li, Chao& Lu, Yiping& Lu, Xiaowei& Du, Sitong…[et al.]. 2016. Blockade of Wntβ-Catenin Pathway Aggravated Silica-Induced Lung Inflammation through Tregs Regulation on Th Immune Responses. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1111147
Modern Language Association (MLA)
Dai, Wujing…[et al.]. Blockade of Wntβ-Catenin Pathway Aggravated Silica-Induced Lung Inflammation through Tregs Regulation on Th Immune Responses. Mediators of Inflammation No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1111147
American Medical Association (AMA)
Dai, Wujing& Liu, Fangwei& Li, Chao& Lu, Yiping& Lu, Xiaowei& Du, Sitong…[et al.]. Blockade of Wntβ-Catenin Pathway Aggravated Silica-Induced Lung Inflammation through Tregs Regulation on Th Immune Responses. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1111147
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111147