Sickness-Associated Anorexia: Mother Nature’s Idea of Immunonutrition?
Joint Authors
Engelbrecht, Anna-Mart
van Niekerk, Gustav
Isaacs, Ashwin W.
Nell, Theo
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-29
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
During an infection, expansion of immune cells, assembly of antibodies, and the induction of a febrile response collectively place continual metabolic strain on the host.
These considerations also provide a rationale for nutritional support in critically ill patients.
Yet, results from clinical and preclinical studies indicate that aggressive nutritional support does not always benefit patients and may occasionally be detrimental.
Moreover, both vertebrates and invertebrates exhibit a decrease in appetite during an infection, indicating that such sickness-associated anorexia (SAA) is evolutionarily conserved.
It also suggests that SAA performs a vital function during an infection.
We review evidence signifying that SAA may present a mechanism by which autophagic flux is upregulated systemically.
A decrease in serum amino acids during an infection promotes autophagy not only in immune cells, but also in nonimmune cells.
Similarly, bile acids reabsorbed postprandially inhibit hepatic autophagy by binding to farnesoid X receptors, indicating that SAA may be an attempt to conserve autophagy.
In addition, augmented autophagic responses may play a critical role in clearing pathogens (xenophagy), in the presentation of epitopes in nonprovisional antigen presenting cells and the removal of damaged proteins and organelles.
Collectively, these observations suggest that some patients might benefit from permissive underfeeding.
American Psychological Association (APA)
van Niekerk, Gustav& Isaacs, Ashwin W.& Nell, Theo& Engelbrecht, Anna-Mart. 2016. Sickness-Associated Anorexia: Mother Nature’s Idea of Immunonutrition?. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1111243
Modern Language Association (MLA)
van Niekerk, Gustav…[et al.]. Sickness-Associated Anorexia: Mother Nature’s Idea of Immunonutrition?. Mediators of Inflammation No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1111243
American Medical Association (AMA)
van Niekerk, Gustav& Isaacs, Ashwin W.& Nell, Theo& Engelbrecht, Anna-Mart. Sickness-Associated Anorexia: Mother Nature’s Idea of Immunonutrition?. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1111243
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111243