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Neuroimmunology of Huntington’s Disease: Revisiting Evidence from Human Studies
Joint Authors
Rocha, Natália Pessoa
Ribeiro, Fabiola M.
Furr-Stimming, Erin
Teixeira, Antonio Lucio
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-08
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Huntington’s disease (HD) is a neurodegenerative disorder characterized by selective loss of neurons in the striatum and cortex, which leads to progressive motor dysfunction, cognitive decline, and psychiatric disorders.
Although the cause of HD is well described—HD is a genetic disorder caused by a trinucleotide (CAG) repeat expansion in the gene encoding for huntingtin (HTT) on chromosome 4p16.3—the ultimate cause of neuronal death is still uncertain.
Apart from impairment in systems for handling abnormal proteins, other metabolic pathways and mechanisms might contribute to neurodegeneration and progression of HD.
Among these, inflammation seems to play a role in HD pathogenesis.
The current review summarizes the available evidence about immune and/or inflammatory changes in HD.
HD is associated with increased inflammatory mediators in both the central nervous system and periphery.
Accordingly, there have been some attempts to slow HD progression targeting the immune system.
American Psychological Association (APA)
Rocha, Natália Pessoa& Ribeiro, Fabiola M.& Furr-Stimming, Erin& Teixeira, Antonio Lucio. 2016. Neuroimmunology of Huntington’s Disease: Revisiting Evidence from Human Studies. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1111268
Modern Language Association (MLA)
Rocha, Natália Pessoa…[et al.]. Neuroimmunology of Huntington’s Disease: Revisiting Evidence from Human Studies. Mediators of Inflammation No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1111268
American Medical Association (AMA)
Rocha, Natália Pessoa& Ribeiro, Fabiola M.& Furr-Stimming, Erin& Teixeira, Antonio Lucio. Neuroimmunology of Huntington’s Disease: Revisiting Evidence from Human Studies. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1111268
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111268