Inhibition of P38 MAPK Downregulates the Expression of IL-1β to Protect Lung from Acute Injury in Intestinal Ischemia Reperfusion Rats
Joint Authors
Zheng, De-Yi
Zhou, Min
Jin, Jiao
He, Mu
Wang, Yi
Du, Jiao
Xiao, Xiang-Yang
Li, Ping-Yang
Ye, Ai-Zhu
Liu, Jia
Wang, Ting-Hua
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-11
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Acute lung injury (ALI) induced by intestinal ischemia/reperfusion (II/R) has high incidence and mortality, in which IL-1β was essential for the full development of ALI.
However, the detailed regulating mechanism for this phenomenon remains to be unclear.
The purpose of this study was to investigate whether inhibition of P38 MAPK could downregulate the expression of IL-1β to protect lung from acute injury in II/R rats.
Here, we found that the level of pulmonary edema at 16 hours after operation (hpo) was obviously enhanced compared to that in 8hpo and sham groups.
Immunofluorescent staining demonstrated that IL-1β and P38 MAPK were detected in lung tissues.
And rats with II/R have the highest translation level for IL-1β and phosphorylation of P38 MAPK in lung tissues at 16hpo compared with 8hpo and sham groups.
Moreover, administration of SB239063, an inhibitor of P38 α and β, could effectively downregulate the expressions of IL-1β and protects lung tissues from injury in II/R rats.
Our findings indicate that the inhibition of P38 α and β may downregulate the expression of IL-1β to protect lung from acute injury in II/R, which could be used as a potential target for reducing ALI induced by II/R in the future clinical trial.
American Psychological Association (APA)
Zheng, De-Yi& Zhou, Min& Jin, Jiao& He, Mu& Wang, Yi& Du, Jiao…[et al.]. 2016. Inhibition of P38 MAPK Downregulates the Expression of IL-1β to Protect Lung from Acute Injury in Intestinal Ischemia Reperfusion Rats. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1111297
Modern Language Association (MLA)
Zheng, De-Yi…[et al.]. Inhibition of P38 MAPK Downregulates the Expression of IL-1β to Protect Lung from Acute Injury in Intestinal Ischemia Reperfusion Rats. Mediators of Inflammation No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1111297
American Medical Association (AMA)
Zheng, De-Yi& Zhou, Min& Jin, Jiao& He, Mu& Wang, Yi& Du, Jiao…[et al.]. Inhibition of P38 MAPK Downregulates the Expression of IL-1β to Protect Lung from Acute Injury in Intestinal Ischemia Reperfusion Rats. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1111297
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111297