Therapeutic Treatment of Arthritic Mice with 15-Deoxy Δ12,14-Prostaglandin J2 (15d-PGJ2) Ameliorates Disease through the Suppression of Th17 Cells and the Induction of CD4+CD25−FOXP3+ Cells
Joint Authors
da Silva, João Santana
Cunha, Fernando Queiroz
Grespan, Renata
Napimoga, Marcelo Henrique
Sacramento, Laís Amorim
Carregaro, Vanessa
Benevides, Luciana
Pinto, Larissa G.
Cunha, Thiago M.
Peres, Raphael Sanches
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-31
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The prostaglandin, 15-deoxy Δ 12,14 -prostaglandin J2 (15d-PGJ2), is a lipid mediator that plays an important role in the control of chronic inflammatory disease.
However, the role of prostanoid in rheumatoid arthritis (RA) is not well determined.
We demonstrated the therapeutic effect of 15d-PGJ2 in an experimental model of arthritis.
Daily administration of 15d-PGJ2 attenuated the severity of CIA, reducing the clinical score, pain, and edema.
15d-PGJ2 treatment was associated with a marked reduction in joint levels of proinflammatory cytokines.
Although the mRNA expression of ROR-γt was profoundly reduced, FOXP3 was enhanced in draining lymph node cells from 15d-PGJ2-treated arthritic mice.
The specific and polyclonal CD4+ Th17 cell responses were limited during the addition of prostaglandin to cell culture.
Moreover, in vitro 15d-PGJ2 increased the expression of FOXP3, GITR, and CTLA-4 in the CD4+CD25− population, suggesting the induction of Tregs on conventional T cells.
Prostanoid addition to CD4+CD25− cells selectively suppressed Th17 differentiation and promoted the enhancement of FOXP3 under polarization conditions.
Thus, 15d-PGJ2 ameliorated symptoms of collagen-induced arthritis by regulating Th17 differentiation, concomitant with the induction of Tregs, and, consequently, protected mice from diseases aggravation.
Altogether, these results indicate that 15d-PGJ2 may represent a potential therapeutic strategy in RA.
American Psychological Association (APA)
Carregaro, Vanessa& Napimoga, Marcelo Henrique& Peres, Raphael Sanches& Benevides, Luciana& Sacramento, Laís Amorim& Pinto, Larissa G.…[et al.]. 2016. Therapeutic Treatment of Arthritic Mice with 15-Deoxy Δ12,14-Prostaglandin J2 (15d-PGJ2) Ameliorates Disease through the Suppression of Th17 Cells and the Induction of CD4+CD25−FOXP3+ Cells. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1111321
Modern Language Association (MLA)
Carregaro, Vanessa…[et al.]. Therapeutic Treatment of Arthritic Mice with 15-Deoxy Δ12,14-Prostaglandin J2 (15d-PGJ2) Ameliorates Disease through the Suppression of Th17 Cells and the Induction of CD4+CD25−FOXP3+ Cells. Mediators of Inflammation No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1111321
American Medical Association (AMA)
Carregaro, Vanessa& Napimoga, Marcelo Henrique& Peres, Raphael Sanches& Benevides, Luciana& Sacramento, Laís Amorim& Pinto, Larissa G.…[et al.]. Therapeutic Treatment of Arthritic Mice with 15-Deoxy Δ12,14-Prostaglandin J2 (15d-PGJ2) Ameliorates Disease through the Suppression of Th17 Cells and the Induction of CD4+CD25−FOXP3+ Cells. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1111321
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111321