Gene × Environment Interactions in Schizophrenia: Evidence from Genetic Mouse Models
Joint Authors
Moran, Paula
Stokes, Jennifer
Marr, Julia
Bock, Gavin
Desbonnet, Lieve
Waddington, John
O’Tuathaigh, Colm
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-23, 23 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-20
Country of Publication
Egypt
No. of Pages
23
Main Subjects
Abstract EN
The study of gene × environment, as well as epistatic interactions in schizophrenia, has provided important insight into the complex etiopathologic basis of schizophrenia.
It has also increased our understanding of the role of susceptibility genes in the disorder and is an important consideration as we seek to translate genetic advances into novel antipsychotic treatment targets.
This review summarises data arising from research involving the modelling of gene × environment interactions in schizophrenia using preclinical genetic models.
Evidence for synergistic effects on the expression of schizophrenia-relevant endophenotypes will be discussed.
It is proposed that valid and multifactorial preclinical models are important tools for identifying critical areas, as well as underlying mechanisms, of convergence of genetic and environmental risk factors, and their interaction in schizophrenia.
American Psychological Association (APA)
Moran, Paula& Stokes, Jennifer& Marr, Julia& Bock, Gavin& Desbonnet, Lieve& Waddington, John…[et al.]. 2016. Gene × Environment Interactions in Schizophrenia: Evidence from Genetic Mouse Models. Neural Plasticity،Vol. 2016, no. 2016, pp.1-23.
https://search.emarefa.net/detail/BIM-1113014
Modern Language Association (MLA)
Moran, Paula…[et al.]. Gene × Environment Interactions in Schizophrenia: Evidence from Genetic Mouse Models. Neural Plasticity No. 2016 (2016), pp.1-23.
https://search.emarefa.net/detail/BIM-1113014
American Medical Association (AMA)
Moran, Paula& Stokes, Jennifer& Marr, Julia& Bock, Gavin& Desbonnet, Lieve& Waddington, John…[et al.]. Gene × Environment Interactions in Schizophrenia: Evidence from Genetic Mouse Models. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-23.
https://search.emarefa.net/detail/BIM-1113014
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113014