A Randomised Controlled Trial of Efficacy of Cognitive Rehabilitation in Multiple Sclerosis: A Cognitive, Behavioural, and MRI Study
Joint Authors
Campbell, J.
Cercignani, Mara
Langdon, D.
Rashid, W.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Aim.
To explore the efficacy of home-based, computerised, cognitive rehabilitation in patients with multiple sclerosis using neuropsychological assessment and advanced structural and functional magnetic resonance imaging (fMRI).
Methods.
38 patients with MS and cognitive impairment on the Brief International Cognitive Assessment for MS (BICAMS) were enrolled.
Patients were randomised to undergo 45 minutes of computerised cognitive rehabilitation using RehaCom software (n=19) three times weekly for six weeks or to a control condition (n=19).
Neuropsychological and MRI data were obtained at baseline (time 1), following the 6-week intervention (time 2), and after a further twelve weeks (time 3).
Cortical activations were explored using fMRI and microstructural changes were explored using quantitative magnetisation transfer (QMT) imaging.
Results.
The treatment group showed a greater improvement in SDMT gain scores between baseline and time 2 compared to the control group (p=0.005).
The treatment group exhibited increased activation in the bilateral prefrontal cortex and right temporoparietal regions relative to control group at time 3 (p<0.05FWE corrected).
No significant changes were observed on QMT.
Conclusion.
This study supports the hypothesis that home-based, computerised, cognitive rehabilitation may be effective in improving cognitive performance in patients with MS.
Clinical trials registration is ISRCTN54901925.
American Psychological Association (APA)
Campbell, J.& Langdon, D.& Cercignani, Mara& Rashid, W.. 2016. A Randomised Controlled Trial of Efficacy of Cognitive Rehabilitation in Multiple Sclerosis: A Cognitive, Behavioural, and MRI Study. Neural Plasticity،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113143
Modern Language Association (MLA)
Campbell, J.…[et al.]. A Randomised Controlled Trial of Efficacy of Cognitive Rehabilitation in Multiple Sclerosis: A Cognitive, Behavioural, and MRI Study. Neural Plasticity No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1113143
American Medical Association (AMA)
Campbell, J.& Langdon, D.& Cercignani, Mara& Rashid, W.. A Randomised Controlled Trial of Efficacy of Cognitive Rehabilitation in Multiple Sclerosis: A Cognitive, Behavioural, and MRI Study. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113143
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113143