Paired-Pulse Parietal-Motor Stimulation Differentially Modulates Corticospinal Excitability across Hemispheres When Combined with Prism Adaptation

Joint Authors

Rossetti, Yves
Farnè, Alessandro
Schintu, Selene
Martín-Arévalo, Elisa
Vesia, Michael
Salemme, Romeo
Pisella, Laure
Reilly, Karen T.

Source

Neural Plasticity

Issue

Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2016-06-22

Country of Publication

Egypt

No. of Pages

9

Main Subjects

Biology
Medicine

Abstract EN

Rightward prism adaptation ameliorates neglect symptoms while leftward prism adaptation (LPA) induces neglect-like biases in healthy individuals.

Similarly, inhibitory repetitive transcranial magnetic stimulation (rTMS) on the right posterior parietal cortex (PPC) induces neglect-like behavior, whereas on the left PPC it ameliorates neglect symptoms and normalizes hyperexcitability of left hemisphere parietal-motor (PPC-M1) connectivity.

Based on this analogy we hypothesized that LPA increases PPC-M1 excitability in the left hemisphere and decreases it in the right one.

In an attempt to shed some light on the mechanisms underlying LPA’s effects on cognition, we investigated this hypothesis in healthy individuals measuring PPC-M1 excitability with dual-site paired-pulse TMS (ppTMS).

We found a left hemisphere increase and a right hemisphere decrease in the amplitude of motor evoked potentials elicited by paired as well as single pulses on M1.

While this could indicate that LPA biases interhemispheric connectivity, it contradicts previous evidence that M1-only MEPs are unchanged after LPA.

A control experiment showed that input-output curves were not affected by LPA per se.

We conclude that LPA combined with ppTMS on PPC-M1 differentially alters the excitability of the left and right M1.

American Psychological Association (APA)

Schintu, Selene& Martín-Arévalo, Elisa& Vesia, Michael& Rossetti, Yves& Salemme, Romeo& Pisella, Laure…[et al.]. 2016. Paired-Pulse Parietal-Motor Stimulation Differentially Modulates Corticospinal Excitability across Hemispheres When Combined with Prism Adaptation. Neural Plasticity،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113192

Modern Language Association (MLA)

Schintu, Selene…[et al.]. Paired-Pulse Parietal-Motor Stimulation Differentially Modulates Corticospinal Excitability across Hemispheres When Combined with Prism Adaptation. Neural Plasticity No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1113192

American Medical Association (AMA)

Schintu, Selene& Martín-Arévalo, Elisa& Vesia, Michael& Rossetti, Yves& Salemme, Romeo& Pisella, Laure…[et al.]. Paired-Pulse Parietal-Motor Stimulation Differentially Modulates Corticospinal Excitability across Hemispheres When Combined with Prism Adaptation. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113192

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1113192