Current Research Therapeutic Strategies for Alzheimer’s Disease Treatment
Joint Authors
Folch, Jaume
Petrov, Dmitry
Ettcheto, Miren
Abad, Sonia
Sánchez-López, Elena
García, M. Luisa
Olloquequi, Jordi
Beas-Zarate, Carlos
Auladell, Carme
Camins, Antoni
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-03
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Alzheimer’s disease (AD) currently presents one of the biggest healthcare issues in the developed countries.
There is no effective treatment capable of slowing down disease progression.
In recent years the main focus of research on novel pharmacotherapies was based on the amyloidogenic hypothesis of AD, which posits that the beta amyloid (Aβ) peptide is chiefly responsible for cognitive impairment and neuronal death.
The goal of such treatments is (a) to reduce Aβ production through the inhibition of β and γ secretase enzymes and (b) to promote dissolution of existing cerebral Aβ plaques.
However, this approach has proven to be only modestly effective.
Recent studies suggest an alternative strategy centred on the inhibition of the downstream Aβ signalling, particularly at the synapse.
Aβ oligomers may cause aberrant N-methyl-D-aspartate receptor (NMDAR) activation postsynaptically by forming complexes with the cell-surface prion protein (PrPC).
PrPC is enriched at the neuronal postsynaptic density, where it interacts with Fyn tyrosine kinase.
Fyn activation occurs when Aβ is bound to PrPC-Fyn complex.
Fyn causes tyrosine phosphorylation of the NR2B subunit of metabotropic glutamate receptor 5 (mGluR5).
Fyn kinase blockers masitinib and saracatinib have proven to be efficacious in treating AD symptoms in experimental mouse models of the disease.
American Psychological Association (APA)
Folch, Jaume& Petrov, Dmitry& Ettcheto, Miren& Abad, Sonia& Sánchez-López, Elena& García, M. Luisa…[et al.]. 2016. Current Research Therapeutic Strategies for Alzheimer’s Disease Treatment. Neural Plasticity،Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1113340
Modern Language Association (MLA)
Folch, Jaume…[et al.]. Current Research Therapeutic Strategies for Alzheimer’s Disease Treatment. Neural Plasticity No. 2016 (2016), pp.1-15.
https://search.emarefa.net/detail/BIM-1113340
American Medical Association (AMA)
Folch, Jaume& Petrov, Dmitry& Ettcheto, Miren& Abad, Sonia& Sánchez-López, Elena& García, M. Luisa…[et al.]. Current Research Therapeutic Strategies for Alzheimer’s Disease Treatment. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1113340
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113340