![](/images/graphics-bg.png)
Nucleolar PARP-1 Expression Is Decreased in Alzheimer’s Disease: Consequences for Epigenetic Regulation of rDNA and Cognition
Joint Authors
Zeng, Jianying
Libien, Jenny
Shaik, Fatima
Wolk, Jason
Hernández, A. Iván
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Synaptic dysfunction is thought to play a major role in memory impairment in Alzheimer’s disease (AD).
PARP-1 has been identified as an epigenetic regulator of plasticity and memory.
Thus, we hypothesize that PARP-1 may be altered in postmortem hippocampus of individuals with AD compared to age-matched controls without neurologic disease.
We found a reduced level of PARP-1 nucleolar immunohistochemical staining in hippocampal pyramidal cells in AD.
Nucleolar PARP-1 staining ranged from dispersed and less intense to entirely absent in AD compared to the distinct nucleolar localization in hippocampal pyramidal neurons in controls.
In cases of AD, the percentage of hippocampal pyramidal cells with nucleoli that were positive for both PARP-1 and the nucleolar marker fibrillarin was significantly lower than in controls.
PARP-1 nucleolar expression emerges as a sensitive marker of functional changes in AD and suggests a novel role for PARP-1 dysregulation in AD pathology.
American Psychological Association (APA)
Zeng, Jianying& Libien, Jenny& Shaik, Fatima& Wolk, Jason& Hernández, A. Iván. 2016. Nucleolar PARP-1 Expression Is Decreased in Alzheimer’s Disease: Consequences for Epigenetic Regulation of rDNA and Cognition. Neural Plasticity،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113369
Modern Language Association (MLA)
Zeng, Jianying…[et al.]. Nucleolar PARP-1 Expression Is Decreased in Alzheimer’s Disease: Consequences for Epigenetic Regulation of rDNA and Cognition. Neural Plasticity No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1113369
American Medical Association (AMA)
Zeng, Jianying& Libien, Jenny& Shaik, Fatima& Wolk, Jason& Hernández, A. Iván. Nucleolar PARP-1 Expression Is Decreased in Alzheimer’s Disease: Consequences for Epigenetic Regulation of rDNA and Cognition. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113369
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113369